[27] Cincinnati 24-13 Notre Dame [20] 2021-10-02 18:30
Stadium: Notre Dame Stadium Round: 1
Home Manager: Brian Kelly Away Manager: Luke Fickell
Home History
| NCAAF | 2021/09/18 16:00 | Cincinnati v Indiana | W | 38-24 |
| NCAAF | 2021/09/11 19:30 | Murray State v Cincinnati | W | 7-42 |
| NCAAF | 2021/09/04 19:30 | Miami Ohio v Cincinnati | W | 14-49 |
| NCAAF | 2021/01/01 17:00 | Cincinnati v Georgia | L | 21-24 |
| NCAAF | 2020/12/20 01:00 | Tulsa v Cincinnati | W | 24-27 |
| NCAAF | 2020/11/21 20:30 | Cincinnati v Central Florida | W | 36-33 |
| NCAAF | 2020/11/14 00:30 | East Carolina v Cincinnati | W | 17-55 |
| NCAAF | 2020/11/07 20:30 | Houston v Cincinnati | W | 10-38 |
Away History
| NCAAF | 2021/09/25 16:00 | Notre Dame v Wisconsin | W | 41-13 |
| NCAAF | 2021/09/18 18:30 | Purdue v Notre Dame | W | 13-27 |
| NCAAF | 2021/09/11 18:30 | Toledo v Notre Dame | W | 29-32 |
| NCAAF | 2021/09/05 23:30 | Notre Dame v Florida State | W | 41-38 |
| NCAAF | 2021/01/01 21:00 | Notre Dame v Alabama | L | 14-31 |
| NCAAF | 2020/12/19 21:00 | Clemson v Notre Dame | L | 34-10 |
| NCAAF | 2020/12/05 19:30 | Syracuse v Notre Dame | W | 21-45 |
| NCAAF | 2020/11/27 20:30 | Notre Dame v North Carolina | W | 31-17 |