[80] USC 16-31 Notre Dame [27] 2021-10-23 23:30
Stadium: Notre Dame Stadium Round: 1
Home Manager: Brian Kelly Away Manager: Donte Williams
Head to Head
| NCAAF | 2019/10/12 23:30 | USC v Notre Dame | L | 27-30 |
| NCAAF | 2018/11/25 01:00 | Notre Dame v USC | L | 24-17 |
| NCAAF | 2017/10/21 23:30 | USC v Notre Dame | L | 14-49 |
| NCAAF | 2016/11/26 20:30 | Notre Dame v USC | W | 27-45 |
| NCAAF | 2015/10/17 23:30 | Notre Dame v USC | L | 41-31 |
| NCAAF | 2014/11/29 20:30 | USC v Notre Dame | W | 49-14 |
| NCAAF | 2012/11/24 12:00 | USC v Notre Dame | L | 13-22 |
| NCAAF | 2011/10/22 12:00 | Notre Dame v USC | W | 17-31 |
Home History
| NCAAF | 2021/10/10 00:00 | Utah v USC | L | 42-26 |
| NCAAF | 2021/10/02 18:00 | USC v Colorado | W | 37-14 |
| NCAAF | 2021/09/26 02:30 | Oregon State v USC | L | 45-27 |
| NCAAF | 2021/09/18 19:30 | USC v Washington State | W | 45-14 |
| NCAAF | 2021/09/12 02:30 | Stanford v USC | L | 42-28 |
| NCAAF | 2021/09/04 21:00 | San Jose State v USC | W | 7-30 |
| NCAAF | 2020/12/19 01:00 | Oregon v USC | L | 31-24 |
| NCAAF | 2020/12/13 00:30 | USC v UCLA | W | 43-38 |
Away History
| NCAAF | 2021/10/09 23:30 | Notre Dame v Virginia Tech | W | 32-29 |
| NCAAF | 2021/10/02 18:30 | Cincinnati v Notre Dame | L | 24-13 |
| NCAAF | 2021/09/25 16:00 | Notre Dame v Wisconsin | W | 41-13 |
| NCAAF | 2021/09/18 18:30 | Purdue v Notre Dame | W | 13-27 |
| NCAAF | 2021/09/11 18:30 | Toledo v Notre Dame | W | 29-32 |
| NCAAF | 2021/09/05 23:30 | Notre Dame v Florida State | W | 41-38 |
| NCAAF | 2021/01/01 21:00 | Notre Dame v Alabama | L | 14-31 |
| NCAAF | 2020/12/19 21:00 | Clemson v Notre Dame | L | 34-10 |