Eastern Kentucky 3-30 Louisville 2021-09-11 23:00
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Walt Wells
Head to Head
| NCAAF | 2019/09/07 23:00 | Eastern Kentucky v Louisville | L | 0-42 |
| NCAAF | 2010/09/11 12:00 | Louisville v Eastern Kentucky | L | 23-13 |
Home History
| NCAAF | 2021/09/04 22:00 | Eastern Kentucky v Western Carolina | W | 31-28 |
| NCAAF | 2020/11/21 20:00 | Western Carolina v Eastern Kentucky | W | 17-49 |
| NCAAF | 2020/11/14 21:00 | Eastern Kentucky v Central Arkansas | L | 25-37 |
| NCAAF | 2020/11/07 20:00 | Stephen F. Austin v Eastern Kentucky | L | 24-6 |
| NCAAF | 2020/10/24 19:00 | Eastern Kentucky v Central Arkansas | W | 31-28 |
| NCAAF | 2020/10/17 19:30 | Eastern Kentucky v Troy | L | 29-31 |
| NCAAF | 2020/10/03 19:00 | Houston Christian v Eastern Kentucky | L | 33-30 |
| NCAAF | 2020/09/26 17:00 | Eastern Kentucky v The Citadel | W | 37-14 |
Away History
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | L | 24-43 |
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | W | 21-45 |
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | L | 27-34 |
| NCAAF | 2020/11/21 00:00 | Syracuse v Louisville | W | 0-30 |
| NCAAF | 2020/11/14 20:30 | Louisville v Virginia | L | 17-31 |
| NCAAF | 2020/10/31 20:00 | Virginia Tech v Louisville | L | 42-35 |
| NCAAF | 2020/10/24 16:00 | Florida State v Louisville | W | 16-48 |
| NCAAF | 2020/10/17 18:30 | Louisville v Notre Dame | L | 7-12 |