[18] Central Florida 35-42 Louisville [89] 2021-09-17 23:30
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Gus Malzahn
Home History
| NCAAF | 2021/09/11 22:30 | Bethune Cookman v Central Florida | W | 14-63 |
| NCAAF | 2021/09/02 23:00 | Boise State v Central Florida | W | 31-36 |
| NCAAF | 2020/12/23 00:00 | Central Florida v BYU | L | 23-49 |
| NCAAF | 2020/11/27 20:30 | Central Florida v South Florida | W | 58-46 |
| NCAAF | 2020/11/21 20:30 | Cincinnati v Central Florida | L | 36-33 |
| NCAAF | 2020/11/15 00:30 | Temple v Central Florida | W | 13-38 |
| NCAAF | 2020/10/31 18:00 | Central Florida v Houston | W | 44-21 |
| NCAAF | 2020/10/24 18:00 | Tulane v Central Florida | W | 34-51 |
Away History
| NCAAF | 2021/09/11 23:00 | Eastern Kentucky v Louisville | W | 3-30 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | L | 24-43 |
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | W | 21-45 |
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | L | 27-34 |
| NCAAF | 2020/11/21 00:00 | Syracuse v Louisville | W | 0-30 |
| NCAAF | 2020/11/14 20:30 | Louisville v Virginia | L | 17-31 |
| NCAAF | 2020/10/31 20:00 | Virginia Tech v Louisville | L | 42-35 |
| NCAAF | 2020/10/24 16:00 | Florida State v Louisville | W | 16-48 |