[17] Alabama 49-9 Mississippi State [65] 2021-10-16 23:00
Stadium: Davis Wade Stadium at Scott Field Round: 1
Home Manager: Mike Leach Away Manager: Nick Saban
Head to Head
| NCAAF | 2020/10/31 23:00 | Mississippi State v Alabama | W | 0-41 |
| NCAAF | 2019/11/16 17:00 | Alabama v Mississippi State | W | 38-7 |
| NCAAF | 2018/11/10 20:30 | Mississippi State v Alabama | W | 0-24 |
| NCAAF | 2017/11/12 00:00 | Alabama v Mississippi State | W | 31-24 |
| NCAAF | 2016/11/12 17:00 | Mississippi State v Alabama | W | 3-51 |
| NCAAF | 2015/11/14 20:30 | Mississippi State v Alabama | W | 6-31 |
| NCAAF | 2014/11/15 20:30 | Alabama v Mississippi State | W | 25-20 |
| NCAAF | 2012/10/27 12:00 | Alabama v Mississippi State | W | 38-7 |
Home History
| NCAAF | 2021/10/16 18:00 | Florida A&M v Alabama | L | 35-31 |
| NCAAF | 2021/10/10 00:00 | Alabama v Texas A&M | L | 38-41 |
| NCAAF | 2021/10/09 19:00 | Jackson State v Alabama | L | 61-15 |
| NCAAF | 2021/10/02 19:30 | Mississippi v Alabama | W | 21-42 |
| NCAAF | 2021/10/02 19:00 | Alabama v Grambling State | L | 28-37 |
| NCAAF | 2021/09/25 23:30 | Southern Mississippi v Alabama | W | 14-63 |
| NCAAF | 2021/09/25 21:00 | Tuskegee v Alabama | W | 35-45 |
| NCAAF | 2021/09/18 19:30 | Alabama v Florida | W | 31-29 |
Away History
| NCAAF | 2021/10/02 23:00 | Mississippi State v Texas A&M | W | 26-22 |
| NCAAF | 2021/09/25 16:00 | LSU v Mississippi State | L | 28-25 |
| NCAAF | 2021/09/18 20:00 | Mississippi State v Memphis | L | 29-31 |
| NCAAF | 2021/09/11 23:00 | NC State v Mississippi State | W | 10-24 |
| NCAAF | 2021/09/04 20:00 | Louisiana Tech v Mississippi State | W | 34-35 |
| NCAAF | 2020/12/31 17:00 | Mississippi State v Tulsa | W | 28-26 |
| NCAAF | 2020/12/19 20:30 | Missouri v Mississippi State | W | 32-51 |
| NCAAF | 2020/12/13 00:30 | Auburn v Mississippi State | L | 24-10 |