[71] LSU 28-25 Mississippi State [43] 2021-09-25 16:00
Stadium: Davis Wade Stadium at Scott Field Round: 1
Home Manager: Mike Leach Away Manager: Ed Orgeron
Head to Head
| NCAAF | 2020/09/26 19:30 | Mississippi State v LSU | L | 44-34 |
| NCAAF | 2019/10/19 19:30 | LSU v Mississippi State | W | 36-13 |
| NCAAF | 2018/10/20 23:00 | Mississippi State v LSU | W | 3-19 |
| NCAAF | 2017/09/16 23:00 | LSU v Mississippi State | L | 7-37 |
| NCAAF | 2016/09/17 23:00 | Mississippi State v LSU | W | 20-23 |
| NCAAF | 2015/09/13 01:15 | Mississippi State v LSU | W | 19-21 |
| NCAAF | 2014/09/20 23:00 | LSU v Mississippi State | L | 29-34 |
| NCAAF | 2012/11/10 12:00 | LSU v Mississippi State | W | 37-17 |
Home History
| NCAAF | 2021/09/18 23:30 | Central Michigan v LSU | W | 21-49 |
| NCAAF | 2021/09/12 00:00 | McNeese State v LSU | W | 7-34 |
| NCAAF | 2021/09/05 00:30 | LSU v UCLA | L | 27-38 |
| NCAAF | 2020/12/19 20:30 | Mississippi v LSU | W | 48-53 |
| NCAAF | 2020/12/13 00:00 | LSU v Florida | W | 37-34 |
| NCAAF | 2020/12/06 01:00 | Alabama v LSU | L | 55-17 |
| NCAAF | 2020/11/29 00:00 | LSU v Texas A&M | L | 7-20 |
| NCAAF | 2020/11/21 17:00 | LSU v Arkansas | W | 27-24 |
Away History
| NCAAF | 2021/09/18 20:00 | Mississippi State v Memphis | L | 29-31 |
| NCAAF | 2021/09/11 23:00 | NC State v Mississippi State | W | 10-24 |
| NCAAF | 2021/09/04 20:00 | Louisiana Tech v Mississippi State | W | 34-35 |
| NCAAF | 2020/12/31 17:00 | Mississippi State v Tulsa | W | 28-26 |
| NCAAF | 2020/12/19 20:30 | Missouri v Mississippi State | W | 32-51 |
| NCAAF | 2020/12/13 00:30 | Auburn v Mississippi State | L | 24-10 |
| NCAAF | 2020/11/28 21:00 | Mississippi State v Mississippi | L | 24-31 |
| NCAAF | 2020/11/22 00:30 | Mississippi State v Georgia | L | 24-31 |