[33] Western Michigan 24-17 Buffalo [77] 2021-10-02 16:00
Stadium: UB Stadium Round: 1
Home Manager: Maurice Linguist Away Manager: Tim Lester
Head to Head
| NCAAF | 2017/10/07 19:30 | Western Michigan v Buffalo | W | 71-68 |
| NCAAF | 2016/11/19 20:30 | Buffalo v Western Michigan | W | 0-38 |
| NCAAF | 2012/11/10 12:00 | Buffalo v Western Michigan | L | 29-24 |
| NCAAF | 2009/10/24 12:00 | Western Michigan v Buffalo | W | 34-31 |
| NCAAF | 2008/10/11 12:00 | Buffalo v Western Michigan | W | 28-34 |
| NCAAF | 2005/10/01 12:00 | Western Michigan v Buffalo | W | 31-21 |
| NCAAF | 2002/10/05 12:00 | Buffalo v Western Michigan | W | 17-31 |
Home History
| NCAAF | 2021/09/25 18:00 | San Jose State v Western Michigan | W | 3-23 |
| NCAAF | 2021/09/18 16:00 | Western Michigan v Pittsburgh | W | 44-41 |
| NCAAF | 2021/09/11 21:00 | Illinois State v Western Michigan | W | 0-28 |
| NCAAF | 2021/09/04 16:00 | Western Michigan v Michigan | L | 14-47 |
| NCAAF | 2020/12/12 17:00 | Western Michigan v Ball State | L | 27-30 |
| NCAAF | 2020/12/05 19:00 | Eastern Michigan v Western Michigan | L | 53-42 |
| NCAAF | 2020/11/28 17:00 | Northern Illinois v Western Michigan | W | 27-30 |
| NCAAF | 2020/11/19 00:00 | Western Michigan v Central Michigan | W | 52-44 |
Away History
| NCAAF | 2021/09/25 22:00 | Buffalo v Old Dominion | W | 35-34 |
| NCAAF | 2021/09/18 16:00 | Coastal Carolina v Buffalo | L | 28-25 |
| NCAAF | 2021/09/11 19:30 | Buffalo v Nebraska | L | 3-28 |
| NCAAF | 2021/09/02 23:00 | Wagner v Buffalo | W | 7-69 |
| NCAAF | 2020/12/25 19:30 | Marshall v Buffalo | W | 10-17 |
| NCAAF | 2020/12/19 00:30 | Ball State v Buffalo | L | 38-28 |
| NCAAF | 2020/12/12 19:30 | Akron v Buffalo | W | 7-56 |
| NCAAF | 2020/11/28 17:00 | Kent State v Buffalo | W | 41-70 |