[69] Tulane 21-61 Mississippi [26] 2021-09-19 00:00
Stadium: Vaught-Hemingway Stadium Round: 1
Home Manager: Lane Kiffin Away Manager: Willie Fritz
Head to Head
| NCAAF | 2012/09/22 12:00 | Mississippi v Tulane | L | 39-0 |
| NCAAF | 2010/09/11 12:00 | Tulane v Mississippi | L | 13-27 |
| NCAAF | 2000/09/02 12:00 | Mississippi v Tulane | L | 49-20 |
Home History
| NCAAF | 2021/09/11 17:00 | Morgan State v Tulane | W | 20-69 |
| NCAAF | 2021/09/04 16:00 | Tulane v Oklahoma | L | 35-40 |
| NCAAF | 2020/12/22 20:30 | Tulane v Nevada | L | 27-38 |
| NCAAF | 2020/12/05 17:00 | Memphis v Tulane | W | 21-35 |
| NCAAF | 2020/11/20 00:30 | Tulane v Tulsa | L | 24-30 |
| NCAAF | 2020/11/14 17:00 | Army v Tulane | W | 12-38 |
| NCAAF | 2020/11/07 17:00 | Tulane v East Carolina | W | 38-21 |
| NCAAF | 2020/10/31 16:00 | Temple v Tulane | W | 3-38 |
Away History
| NCAAF | 2021/09/11 23:30 | Austin Peay v Mississippi | W | 17-54 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | W | 24-43 |
| NCAAF | 2021/01/02 17:30 | Mississippi v Indiana | W | 26-20 |
| NCAAF | 2020/12/19 20:30 | Mississippi v LSU | L | 48-53 |
| NCAAF | 2020/11/28 21:00 | Mississippi State v Mississippi | W | 24-31 |
| NCAAF | 2020/11/15 00:30 | South Carolina v Mississippi | W | 42-59 |
| NCAAF | 2020/10/31 20:00 | Mississippi v Vanderbilt | W | 54-21 |
| NCAAF | 2020/10/24 16:00 | Auburn v Mississippi | L | 35-28 |