[19] Liberty 14-27 Mississippi [34] 2021-11-06 16:00
Stadium: Vaught-Hemingway Stadium Round: 1
Home Manager: Lane Kiffin Away Manager: Hugh Freeze
Home History
| NCAAF | 2021/10/30 16:00 | Massachusetts v Liberty | W | 17-62 |
| NCAAF | 2021/10/23 20:00 | Liberty v North Texas | W | 35-26 |
| NCAAF | 2021/10/16 23:00 | Liberty v UL Monroe | L | 28-31 |
| NCAAF | 2021/10/09 19:30 | Middle Tennessee St. v Liberty | W | 13-41 |
| NCAAF | 2021/10/02 23:00 | Liberty v UAB | W | 36-12 |
| NCAAF | 2021/09/25 00:00 | Liberty v Syracuse | L | 21-24 |
| NCAAF | 2021/09/18 22:00 | Old Dominion v Liberty | W | 17-45 |
| NCAAF | 2021/09/11 23:00 | Liberty v Troy | W | 21-13 |
Away History
| NCAAF | 2021/10/30 23:00 | Mississippi v Auburn | L | 20-31 |
| NCAAF | 2021/10/23 19:30 | LSU v Mississippi | W | 17-31 |
| NCAAF | 2021/10/16 23:30 | Mississippi v Tennessee | W | 31-26 |
| NCAAF | 2021/10/09 16:00 | Arkansas v Mississippi | W | 51-52 |
| NCAAF | 2021/10/02 19:30 | Mississippi v Alabama | L | 21-42 |
| NCAAF | 2021/09/19 00:00 | Tulane v Mississippi | W | 21-61 |
| NCAAF | 2021/09/11 23:30 | Austin Peay v Mississippi | W | 17-54 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | W | 24-43 |