Clemson 30-0 South Carolina 2021-11-28 00:30
Stadium: Williams-Brice Stadium Round: 1
Home Manager: Shane Beamer Away Manager: Dabo Swinney
Head to Head
| NCAAF | 2019/11/30 17:00 | Clemson v South Carolina | W | 38-3 |
| NCAAF | 2018/11/25 00:00 | South Carolina v Clemson | W | 35-56 |
| NCAAF | 2017/11/26 00:30 | Clemson v South Carolina | W | 34-10 |
| NCAAF | 2016/11/27 00:30 | South Carolina v Clemson | W | 7-56 |
| NCAAF | 2015/11/28 17:00 | South Carolina v Clemson | W | 32-37 |
| NCAAF | 2014/11/29 17:00 | Clemson v South Carolina | W | 35-17 |
| NCAAF | 2012/11/24 12:00 | Clemson v South Carolina | L | 17-27 |
| NCAAF | 2011/11/26 12:00 | South Carolina v Clemson | L | 34-13 |
Home History
| NCAAF | 2021/11/20 17:00 | Wake Forest v Clemson | W | 27-48 |
| NCAAF | 2021/11/13 17:00 | Connecticut v Clemson | W | 7-44 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | W | 30-24 |
| NCAAF | 2021/10/30 19:30 | Florida State v Clemson | W | 20-30 |
| NCAAF | 2021/10/23 19:30 | Clemson v Pittsburgh | L | 17-27 |
| NCAAF | 2021/10/15 23:00 | Clemson v Syracuse | W | 17-14 |
| NCAAF | 2021/10/02 23:30 | Boston College v Clemson | W | 13-19 |
| NCAAF | 2021/09/25 19:30 | Clemson v NC State | L | 21-27 |
Away History
| NCAAF | 2021/11/21 00:00 | Auburn v South Carolina | W | 17-21 |
| NCAAF | 2021/11/13 21:00 | South Carolina v Missouri | L | 28-31 |
| NCAAF | 2021/11/06 23:30 | Florida v South Carolina | W | 17-40 |
| NCAAF | 2021/10/23 23:30 | South Carolina v Texas A&M | L | 14-44 |
| NCAAF | 2021/10/16 20:00 | Vanderbilt v South Carolina | W | 20-21 |
| NCAAF | 2021/10/09 16:00 | South Carolina v Tennessee | L | 20-45 |
| NCAAF | 2021/10/02 19:30 | Troy v South Carolina | W | 14-23 |
| NCAAF | 2021/09/25 23:00 | Kentucky v South Carolina | L | 16-10 |