[113] Ohio 34-26 Eastern Michigan [49] 2021-11-10 01:00
Stadium: Rynearson Stadium Round: 1
Home Manager: Chris Creighton Away Manager: Tim Albin
Head to Head
| NCAAF | 2017/09/23 18:00 | Ohio v Eastern Michigan | W | 27-20 |
| NCAAF | 2016/10/15 18:00 | Eastern Michigan v Ohio | L | 27-20 |
| NCAAF | 2010/10/02 12:00 | Eastern Michigan v Ohio | W | 17-30 |
| NCAAF | 2007/10/13 12:00 | Ohio v Eastern Michigan | W | 48-42 |
| NCAAF | 2006/11/04 12:00 | Eastern Michigan v Ohio | W | 10-16 |
| NCAAF | 2002/10/12 12:00 | Ohio v Eastern Michigan | W | 55-27 |
Home History
| NCAAF | 2021/11/02 23:30 | Miami Ohio v Ohio | W | 33-35 |
| NCAAF | 2021/10/23 17:00 | Kent State v Ohio | L | 34-27 |
| NCAAF | 2021/10/16 16:00 | Ohio v Buffalo | L | 26-27 |
| NCAAF | 2021/10/09 19:30 | Central Michigan v Ohio | L | 30-27 |
| NCAAF | 2021/10/02 19:30 | Ohio v Akron | W | 34-17 |
| NCAAF | 2021/09/25 16:00 | Ohio v Northwestern | L | 6-35 |
| NCAAF | 2021/09/17 00:00 | Ohio v Lafayette | L | 14-49 |
| NCAAF | 2021/09/11 18:00 | Duquesne v Ohio | L | 28-26 |
Away History
| NCAAF | 2021/11/02 23:30 | Eastern Michigan v Toledo | W | 52-49 |
| NCAAF | 2021/10/23 16:00 | Eastern Michigan v Bowling Green | W | 55-24 |
| NCAAF | 2021/10/16 18:00 | Ball State v Eastern Michigan | L | 38-31 |
| NCAAF | 2021/10/09 19:30 | Miami Ohio v Eastern Michigan | W | 12-13 |
| NCAAF | 2021/10/02 18:30 | Eastern Michigan v Northern Illinois | L | 20-27 |
| NCAAF | 2021/09/25 18:00 | Texas State v Eastern Michigan | W | 21-59 |
| NCAAF | 2021/09/18 19:30 | Eastern Michigan v Massachusetts | W | 42-28 |
| NCAAF | 2021/09/11 23:00 | Eastern Michigan v Wisconsin | L | 7-34 |