[58] Western Michigan 21-22 Eastern Michigan [53] 2021-11-17 00:30
Stadium: Rynearson Stadium Round: 1
Home Manager: Chris Creighton Away Manager: Tim Lester
Head to Head
| NCAAF | 2020/12/05 19:00 | Eastern Michigan v Western Michigan | L | 53-42 |
| NCAAF | 2019/10/19 23:00 | Western Michigan v Eastern Michigan | L | 27-34 |
| NCAAF | 2018/10/06 16:00 | Eastern Michigan v Western Michigan | W | 24-27 |
| NCAAF | 2017/10/21 18:00 | Western Michigan v Eastern Michigan | W | 20-17 |
| NCAAF | 2016/10/22 19:30 | Eastern Michigan v Western Michigan | W | 31-45 |
| NCAAF | 2015/10/29 23:30 | Eastern Michigan v Western Michigan | W | 28-58 |
| NCAAF | 2014/11/15 19:00 | Western Michigan v Eastern Michigan | W | 51-7 |
| NCAAF | 2012/11/17 12:00 | Western Michigan v Eastern Michigan | L | 23-29 |
Home History
| NCAAF | 2021/11/10 00:00 | Akron v Western Michigan | W | 40-45 |
| NCAAF | 2021/11/03 23:00 | Central Michigan v Western Michigan | L | 42-30 |
| NCAAF | 2021/10/23 19:30 | Western Michigan v Toledo | L | 15-34 |
| NCAAF | 2021/10/16 19:30 | Kent State v Western Michigan | W | 31-64 |
| NCAAF | 2021/10/09 19:30 | Ball State v Western Michigan | L | 45-20 |
| NCAAF | 2021/10/02 16:00 | Western Michigan v Buffalo | W | 24-17 |
| NCAAF | 2021/09/25 18:00 | San Jose State v Western Michigan | W | 3-23 |
| NCAAF | 2021/09/18 16:00 | Western Michigan v Pittsburgh | W | 44-41 |
Away History
| NCAAF | 2021/11/10 01:00 | Ohio v Eastern Michigan | L | 34-26 |
| NCAAF | 2021/11/02 23:30 | Eastern Michigan v Toledo | W | 52-49 |
| NCAAF | 2021/10/23 16:00 | Eastern Michigan v Bowling Green | W | 55-24 |
| NCAAF | 2021/10/16 18:00 | Ball State v Eastern Michigan | L | 38-31 |
| NCAAF | 2021/10/09 19:30 | Miami Ohio v Eastern Michigan | W | 12-13 |
| NCAAF | 2021/10/02 18:30 | Eastern Michigan v Northern Illinois | L | 20-27 |
| NCAAF | 2021/09/25 18:00 | Texas State v Eastern Michigan | W | 21-59 |
| NCAAF | 2021/09/18 19:30 | Eastern Michigan v Massachusetts | W | 42-28 |