[43] Eastern Michigan 20-27 Northern Illinois [70] 2021-10-02 18:30
Stadium: Brigham Field at Huskie Stadium Round: 1
Home Manager: Thomas Hammock Away Manager: Chris Creighton
Head to Head
| NCAAF | 2020/12/12 17:00 | Northern Illinois v Eastern Michigan | W | 33-41 |
| NCAAF | 2019/11/20 00:30 | Eastern Michigan v Northern Illinois | W | 45-17 |
| NCAAF | 2018/09/29 22:00 | Northern Illinois v Eastern Michigan | L | 26-23 |
| NCAAF | 2017/10/27 01:00 | Northern Illinois v Eastern Michigan | L | 30-27 |
| NCAAF | 2016/11/17 01:00 | Northern Illinois v Eastern Michigan | L | 31-24 |
| NCAAF | 2015/10/24 19:30 | Northern Illinois v Eastern Michigan | L | 49-21 |
| NCAAF | 2014/10/25 17:00 | Eastern Michigan v Northern Illinois | L | 17-28 |
| NCAAF | 2012/11/23 12:00 | Eastern Michigan v Northern Illinois | L | 7-49 |
Home History
| NCAAF | 2021/09/25 18:00 | Texas State v Eastern Michigan | W | 21-59 |
| NCAAF | 2021/09/18 19:30 | Eastern Michigan v Massachusetts | W | 42-28 |
| NCAAF | 2021/09/11 23:00 | Eastern Michigan v Wisconsin | L | 7-34 |
| NCAAF | 2021/09/03 23:00 | St.Francis (PA) v Eastern Michigan | W | 15-35 |
| NCAAF | 2020/12/12 17:00 | Northern Illinois v Eastern Michigan | W | 33-41 |
| NCAAF | 2020/12/05 19:00 | Eastern Michigan v Western Michigan | W | 53-42 |
| NCAAF | 2020/11/27 21:00 | Central Michigan v Eastern Michigan | L | 31-23 |
| NCAAF | 2020/11/19 00:00 | Toledo v Eastern Michigan | L | 45-28 |
Away History
| NCAAF | 2021/09/25 18:30 | Maine v Northern Illinois | W | 14-41 |
| NCAAF | 2021/09/18 16:00 | Northern Illinois v Michigan | L | 10-63 |
| NCAAF | 2021/09/11 17:30 | Wyoming v Northern Illinois | L | 50-43 |
| NCAAF | 2021/09/04 23:30 | Northern Illinois v Georgia Tech | W | 22-21 |
| NCAAF | 2020/12/12 17:00 | Northern Illinois v Eastern Michigan | L | 33-41 |
| NCAAF | 2020/12/05 17:00 | Toledo v Northern Illinois | L | 41-24 |
| NCAAF | 2020/11/28 17:00 | Northern Illinois v Western Michigan | L | 27-30 |
| NCAAF | 2020/11/19 00:00 | Northern Illinois v Ball State | L | 25-31 |