[12] UL Lafayette 42-14 Liberty [31] 2021-11-20 21:00
Stadium: Williams Stadium Round: 1
Home Manager: Hugh Freeze Away Manager: Billy Napier
Home History
| NCAAF | 2021/11/20 17:00 | Lafayette v Lehigh | L | 10-17 |
| NCAAF | 2021/11/13 20:30 | Lafayette v Troy | W | 35-21 |
| NCAAF | 2021/11/13 17:30 | Colgate v Lafayette | L | 20-13 |
| NCAAF | 2021/11/06 16:30 | Lafayette v Holy Cross | L | 10-35 |
| NCAAF | 2021/11/04 23:30 | Georgia State v Lafayette | W | 17-21 |
| NCAAF | 2021/10/30 16:30 | Lafayette v Georgetown | W | 24-23 |
| NCAAF | 2021/10/30 16:00 | Texas State v Lafayette | W | 0-45 |
| NCAAF | 2021/10/21 23:30 | Lafayette v Arkansas State | W | 28-27 |
Away History
| NCAAF | 2021/11/06 16:00 | Liberty v Mississippi | L | 14-27 |
| NCAAF | 2021/10/30 16:00 | Massachusetts v Liberty | W | 17-62 |
| NCAAF | 2021/10/23 20:00 | Liberty v North Texas | W | 35-26 |
| NCAAF | 2021/10/16 23:00 | Liberty v UL Monroe | L | 28-31 |
| NCAAF | 2021/10/09 19:30 | Middle Tennessee St. v Liberty | W | 13-41 |
| NCAAF | 2021/10/02 23:00 | Liberty v UAB | W | 36-12 |
| NCAAF | 2021/09/25 00:00 | Liberty v Syracuse | L | 21-24 |
| NCAAF | 2021/09/18 22:00 | Old Dominion v Liberty | W | 17-45 |