[68] South Alabama 7-31 Appalachian State [23] 2021-11-13 19:30
Stadium: Kidd Brewer Stadium Round: 1
Home Manager: Shawn Clark Away Manager: Kane Wommack
Head to Head
| NCAAF | 2019/10/26 16:00 | Appalachian St v South Alabama | L | 30-3 |
| NCAAF | 2018/09/29 19:30 | South Alabama v Appalachian St | L | 7-52 |
| NCAAF | 2015/12/06 00:30 | South Alabama v Appalachian St | L | 27-34 |
| NCAAF | 2014/10/04 22:00 | Appalachian St v South Alabama | W | 21-47 |
Home History
| NCAAF | 2021/11/06 19:30 | South Alabama v Troy | L | 24-31 |
| NCAAF | 2021/10/30 21:00 | Arkansas State v South Alabama | W | 13-31 |
| NCAAF | 2021/10/23 23:00 | South Alabama v UL Monroe | L | 31-41 |
| NCAAF | 2021/10/14 23:30 | Georgia Southern v South Alabama | W | 14-41 |
| NCAAF | 2021/10/09 23:00 | South Alabama v Texas State | L | 31-33 |
| NCAAF | 2021/10/03 00:00 | Lafayette v South Alabama | L | 20-18 |
| NCAAF | 2021/09/19 00:00 | Alcorn State v South Alabama | W | 21-28 |
| NCAAF | 2021/09/11 20:00 | South Alabama v Bowling Green | W | 22-19 |
Away History
| NCAAF | 2021/11/06 18:00 | Appalachian St v Arkansas State | W | 48-14 |
| NCAAF | 2021/10/30 19:30 | UL Monroe v Appalachian St | W | 28-59 |
| NCAAF | 2021/10/20 23:30 | Coastal Carolina v Appalachian St | W | 27-30 |
| NCAAF | 2021/10/12 23:30 | Appalachian St v Lafayette | L | 13-41 |
| NCAAF | 2021/10/02 18:00 | Appalachian St v Georgia State | W | 45-16 |
| NCAAF | 2021/09/23 23:30 | Marshall v Appalachian St | W | 30-31 |
| NCAAF | 2021/09/18 19:30 | Elon v Appalachian St | W | 10-44 |
| NCAAF | 2021/09/11 23:00 | Appalachian St v Miami Florida | L | 23-25 |