[117] Ohio 14-49 UL Lafayette [105] 2021-09-17 00:00
Stadium: Cajun Field Round: 1
Home Manager: Billy Napier Away Manager: Tim Albin
Head to Head
| NCAAF | 2019/09/21 18:00 | Lafayette v Ohio | L | 45-25 |
| NCAAF | 2010/10/30 12:00 | Ohio v Lafayette | W | 38-31 |
| NCAAF | 2007/09/08 12:00 | Lafayette v Ohio | W | 23-31 |
Home History
| NCAAF | 2021/09/11 18:00 | Duquesne v Ohio | L | 28-26 |
| NCAAF | 2021/09/04 23:00 | Syracuse v Ohio | L | 29-9 |
| NCAAF | 2020/11/28 17:00 | Bowling Green v Ohio | W | 10-52 |
| NCAAF | 2020/11/11 00:00 | Akron v Ohio | W | 10-24 |
| NCAAF | 2020/11/05 00:00 | Ohio v Central Michigan | L | 27-30 |
| NCAAF | 2020/01/03 20:30 | Ohio v Nevada | W | 30-21 |
| NCAAF | 2019/11/26 23:00 | Ohio v Akron | W | 52-3 |
| NCAAF | 2019/11/20 00:30 | Ohio v Bowling Green | W | 66-24 |
Away History
| NCAAF | 2021/09/11 23:00 | Nicholls State v Lafayette | W | 24-27 |
| NCAAF | 2021/09/11 22:00 | Lafayette v William & Mary | L | 3-24 |
| NCAAF | 2021/09/04 20:30 | Lafayette v Texas | L | 18-38 |
| NCAAF | 2021/09/04 18:00 | Lafayette v Air Force | L | 14-35 |
| NCAAF | 2021/04/10 16:30 | Lehigh v Lafayette | W | 13-20 |
| NCAAF | 2021/03/27 20:00 | Lafayette v Bucknell | L | 13-38 |
| NCAAF | 2021/03/13 20:30 | Colgate v Lafayette | W | 10-24 |
| NCAAF | 2020/12/26 20:30 | Lafayette v Texas-San Antonio | W | 31-24 |