[29] Appalachian State 13-41 UL Lafayette [34] 2021-10-12 23:30
Stadium: Cajun Field Round: 1
Home Manager: Billy Napier Away Manager: Shawn Clark
Head to Head
| NCAAF | 2020/12/05 01:30 | Lafayette v Appalachian St | L | 24-21 |
| NCAAF | 2019/12/07 17:00 | Lafayette v Appalachian St | W | 38-45 |
| NCAAF | 2019/10/10 00:00 | Appalachian St v Lafayette | W | 17-7 |
| NCAAF | 2018/12/01 17:00 | Lafayette v Appalachian St | W | 19-30 |
| NCAAF | 2018/10/20 19:30 | Lafayette v Appalachian St | W | 17-27 |
| NCAAF | 2017/12/02 19:30 | Lafayette v Appalachian St | W | 14-63 |
| NCAAF | 2016/10/13 00:00 | Appalachian St v Lafayette | W | 24-0 |
| NCAAF | 2015/11/28 19:00 | Appalachian St v Lafayette | W | 28-7 |
Home History
| NCAAF | 2021/10/02 18:00 | Appalachian St v Georgia State | W | 45-16 |
| NCAAF | 2021/09/23 23:30 | Marshall v Appalachian St | W | 30-31 |
| NCAAF | 2021/09/18 19:30 | Elon v Appalachian St | W | 10-44 |
| NCAAF | 2021/09/11 23:00 | Appalachian St v Miami Florida | L | 23-25 |
| NCAAF | 2021/09/02 23:30 | East Carolina v Appalachian St | W | 19-33 |
| NCAAF | 2020/12/21 19:30 | North Texas v Appalachian St | W | 28-56 |
| NCAAF | 2020/12/12 23:00 | Appalachian St v Georgia Southern | W | 34-26 |
| NCAAF | 2020/12/05 01:30 | Lafayette v Appalachian St | L | 24-21 |
Away History
| NCAAF | 2021/10/09 16:30 | Bucknell v Lafayette | W | 0-27 |
| NCAAF | 2021/10/03 00:00 | Lafayette v South Alabama | W | 20-18 |
| NCAAF | 2021/10/02 19:30 | Fordham v Lafayette | L | 42-41 |
| NCAAF | 2021/09/25 22:00 | Lafayette v Georgia Southern | W | 28-20 |
| NCAAF | 2021/09/25 19:30 | Pennsylvania v Lafayette | W | 14-24 |
| NCAAF | 2021/09/18 16:30 | New Hampshire v Lafayette | L | 19-13 |
| NCAAF | 2021/09/17 00:00 | Ohio v Lafayette | W | 14-49 |
| NCAAF | 2021/09/11 23:00 | Nicholls State v Lafayette | W | 24-27 |