[111] Southern Miss 19-24 Rice [117] 2021-10-02 22:30
Stadium: Rice Stadium Round: 1
Home Manager: Mike Bloomgren Away Manager: Will Hall
Head to Head
| NCAAF | 2020/10/31 19:00 | Rice v Southern Mississippi | L | 30-6 |
| NCAAF | 2019/10/26 17:00 | Southern Mississippi v Rice | W | 20-6 |
| NCAAF | 2018/09/22 23:00 | Rice v Southern Mississippi | W | 22-40 |
| NCAAF | 2017/11/11 20:30 | Southern Mississippi v Rice | W | 43-34 |
| NCAAF | 2016/10/01 23:00 | Rice v Southern Mississippi | W | 28-44 |
| NCAAF | 2015/11/14 20:30 | Rice v Southern Mississippi | W | 10-65 |
| NCAAF | 2014/09/27 23:00 | Southern Mississippi v Rice | L | 23-41 |
| NCAAF | 2012/10/27 12:00 | Rice v Southern Mississippi | L | 44-17 |
Home History
| NCAAF | 2021/09/25 23:30 | Southern Mississippi v Alabama | L | 14-63 |
| NCAAF | 2021/09/18 23:00 | Troy v Southern Mississippi | L | 21-9 |
| NCAAF | 2021/09/11 23:00 | Grambling State v Southern Mississippi | W | 0-37 |
| NCAAF | 2021/09/05 00:00 | Southern Mississippi v South Alabama | L | 7-31 |
| NCAAF | 2020/12/10 23:30 | Florida Atlantic v Southern Mississippi | W | 31-45 |
| NCAAF | 2020/11/21 20:00 | Texas-San Antonio v Southern Mississippi | L | 23-20 |
| NCAAF | 2020/11/14 20:30 | Southern Mississippi v Western Kentucky | L | 7-10 |
| NCAAF | 2020/11/07 20:00 | North Alabama v Southern Mississippi | W | 13-24 |
Away History
| NCAAF | 2021/09/25 22:30 | Texas Southern Tigers v Rice | W | 34-48 |
| NCAAF | 2021/09/19 00:00 | Rice v Texas | L | 0-58 |
| NCAAF | 2021/09/11 22:30 | Houston v Rice | L | 44-7 |
| NCAAF | 2021/09/04 18:00 | Rice v Arkansas | L | 17-38 |
| NCAAF | 2020/12/12 18:00 | UAB v Rice | L | 21-16 |
| NCAAF | 2020/12/05 17:00 | Rice v Marshall | W | 20-0 |
| NCAAF | 2020/11/21 19:00 | Rice v North Texas | L | 17-27 |
| NCAAF | 2020/10/31 19:00 | Rice v Southern Mississippi | W | 30-6 |