[92] Florida State 20-30 Clemson [51] 2021-10-30 19:30
Stadium: Memorial Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Mike Norvell
Head to Head
| NCAAF | 2019/10/12 19:30 | Clemson v Florida State | L | 45-14 |
| NCAAF | 2018/10/27 16:00 | Florida State v Clemson | L | 10-59 |
| NCAAF | 2018/10/27 16:00 | Clemson v Florida State | L | 59-10 |
| NCAAF | 2017/11/11 20:30 | Florida State v Clemson | L | 14-31 |
| NCAAF | 2016/10/30 00:00 | Clemson v Florida State | L | 37-34 |
| NCAAF | 2015/11/07 20:30 | Clemson v Florida State | L | 23-13 |
| NCAAF | 2014/09/21 00:00 | Florida State v Clemson | W | 23-17 |
| NCAAF | 2012/09/22 12:00 | Florida State v Clemson | W | 49-37 |
Home History
| NCAAF | 2021/10/23 16:00 | Massachusetts v Florida State | W | 3-59 |
| NCAAF | 2021/10/09 19:30 | Florida State v North Carolina | W | 35-25 |
| NCAAF | 2021/10/02 19:30 | Syracuse v Florida State | W | 30-33 |
| NCAAF | 2021/09/25 19:30 | Louisville v Florida State | L | 31-23 |
| NCAAF | 2021/09/18 19:30 | Florida State v Wake Forest | L | 14-35 |
| NCAAF | 2021/09/12 00:00 | Jacksonville State v Florida State | L | 20-17 |
| NCAAF | 2021/09/05 23:30 | Notre Dame v Florida State | L | 41-38 |
| NCAAF | 2020/12/12 21:00 | Duke v Florida State | W | 35-56 |
Away History
| NCAAF | 2021/10/23 19:30 | Clemson v Pittsburgh | L | 17-27 |
| NCAAF | 2021/10/15 23:00 | Clemson v Syracuse | W | 17-14 |
| NCAAF | 2021/10/02 23:30 | Boston College v Clemson | W | 13-19 |
| NCAAF | 2021/09/25 19:30 | Clemson v NC State | L | 21-27 |
| NCAAF | 2021/09/18 19:30 | Georgia Tech v Clemson | W | 8-14 |
| NCAAF | 2021/09/11 21:00 | South Carolina State v Clemson | W | 3-49 |
| NCAAF | 2021/09/04 23:30 | Georgia v Clemson | L | 10-3 |
| NCAAF | 2021/01/02 01:00 | Ohio State v Clemson | L | 49-28 |