[62] Louisville 13-28 NC State [36] 2021-10-30 23:30
Stadium: Wayne Day Family Field at Carter-Finley Stadium Round: 1
Home Manager: Dave Doeren Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2019/11/17 00:30 | Louisville v NC State | W | 34-20 |
| NCAAF | 2018/11/17 17:20 | NC State v Louisville | L | 52-10 |
| NCAAF | 2017/10/06 00:00 | Louisville v NC State | L | 25-39 |
| NCAAF | 2016/10/22 16:00 | NC State v Louisville | W | 13-54 |
| NCAAF | 2015/10/03 16:30 | NC State v Louisville | W | 13-20 |
| NCAAF | 2014/10/18 19:30 | Louisville v NC State | W | 30-18 |
| NCAAF | 2007/09/29 12:00 | NC State v Louisville | W | 10-29 |
Home History
| NCAAF | 2021/10/23 20:00 | Boston College v Louisville | W | 14-28 |
| NCAAF | 2021/10/09 19:00 | Virginia v Louisville | L | 34-33 |
| NCAAF | 2021/10/02 16:30 | Louisville v Wake Forest | L | 34-37 |
| NCAAF | 2021/09/25 19:30 | Louisville v Florida State | W | 31-23 |
| NCAAF | 2021/09/17 23:30 | Central Florida v Louisville | W | 35-42 |
| NCAAF | 2021/09/11 23:00 | Eastern Kentucky v Louisville | W | 3-30 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | L | 24-43 |
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | W | 21-45 |
Away History
| NCAAF | 2021/10/23 23:30 | NC State v Miami Florida | L | 30-31 |
| NCAAF | 2021/10/16 23:30 | NC State v Boston College | W | 33-7 |
| NCAAF | 2021/10/02 22:00 | Louisiana Tech v NC State | W | 27-34 |
| NCAAF | 2021/09/25 19:30 | Clemson v NC State | W | 21-27 |
| NCAAF | 2021/09/18 23:30 | Furman v NC State | W | 7-45 |
| NCAAF | 2021/09/11 23:00 | NC State v Mississippi State | L | 10-24 |
| NCAAF | 2021/09/02 23:30 | South Florida v NC State | W | 0-45 |
| NCAAF | 2021/01/02 17:00 | Kentucky v NC State | L | 23-21 |