[47] UL Lafayette 20-18 South Alabama [33] 2021-10-03 00:00
Stadium: Hancock Whitney Stadium Round: 1
Home Manager: Kane Wommack Away Manager: Billy Napier
Head to Head
| NCAAF | 2020/11/14 19:00 | South Alabama v Lafayette | W | 10-38 |
| NCAAF | 2019/11/16 22:00 | Lafayette v South Alabama | W | 37-27 |
| NCAAF | 2018/11/17 22:00 | South Alabama v Lafayette | W | 38-48 |
| NCAAF | 2017/11/04 20:00 | Lafayette v South Alabama | W | 19-14 |
| NCAAF | 2016/09/17 23:00 | Lafayette v South Alabama | W | 28-23 |
| NCAAF | 2015/11/13 00:30 | South Alabama v Lafayette | L | 32-25 |
| NCAAF | 2014/11/01 21:00 | Lafayette v South Alabama | W | 19-9 |
| NCAAF | 2012/11/24 12:00 | Lafayette v South Alabama | W | 52-30 |
Home History
| NCAAF | 2021/10/02 19:30 | Fordham v Lafayette | L | 42-41 |
| NCAAF | 2021/09/25 22:00 | Lafayette v Georgia Southern | W | 28-20 |
| NCAAF | 2021/09/25 19:30 | Pennsylvania v Lafayette | W | 14-24 |
| NCAAF | 2021/09/18 16:30 | New Hampshire v Lafayette | L | 19-13 |
| NCAAF | 2021/09/17 00:00 | Ohio v Lafayette | W | 14-49 |
| NCAAF | 2021/09/11 23:00 | Nicholls State v Lafayette | W | 24-27 |
| NCAAF | 2021/09/11 22:00 | Lafayette v William & Mary | L | 3-24 |
| NCAAF | 2021/09/04 20:30 | Lafayette v Texas | L | 18-38 |
Away History
| NCAAF | 2021/09/19 00:00 | Alcorn State v South Alabama | W | 21-28 |
| NCAAF | 2021/09/11 20:00 | South Alabama v Bowling Green | W | 22-19 |
| NCAAF | 2021/09/05 00:00 | Southern Mississippi v South Alabama | W | 7-31 |
| NCAAF | 2020/12/05 19:00 | Troy v South Alabama | L | 29-0 |
| NCAAF | 2020/11/28 20:00 | South Alabama v Arkansas State | W | 38-31 |
| NCAAF | 2020/11/21 20:30 | Georgia State v South Alabama | L | 31-14 |
| NCAAF | 2020/11/14 19:00 | South Alabama v Lafayette | L | 10-38 |
| NCAAF | 2020/11/08 01:00 | South Alabama v Coastal Carolina | L | 6-23 |