[106] Georgia Southern 14-41 South Alabama [58] 2021-10-14 23:30
Stadium: Hancock Whitney Stadium Round: 1
Home Manager: Kane Wommack Away Manager: Chad Lunsford
Head to Head
| NCAAF | 2020/10/29 23:30 | South Alabama v Georgia Southern | W | 17-24 |
| NCAAF | 2019/10/03 23:30 | Georgia Southern v South Alabama | W | 20-17 |
| NCAAF | 2018/10/06 19:30 | South Alabama v Georgia Southern | W | 13-48 |
| NCAAF | 2017/11/18 20:00 | South Alabama v Georgia Southern | W | 0-52 |
| NCAAF | 2016/09/10 23:00 | South Alabama v Georgia Southern | W | 9-24 |
| NCAAF | 2015/11/28 19:00 | Georgia Southern v South Alabama | W | 55-17 |
| NCAAF | 2014/09/20 23:30 | South Alabama v Georgia Southern | W | 6-28 |
Home History
| NCAAF | 2021/10/09 23:00 | Georgia Southern v Troy | L | 24-27 |
| NCAAF | 2021/10/02 20:00 | Arkansas State v Georgia Southern | W | 33-59 |
| NCAAF | 2021/09/25 22:00 | Lafayette v Georgia Southern | L | 28-20 |
| NCAAF | 2021/09/18 20:00 | Georgia Southern v Arkansas | L | 10-45 |
| NCAAF | 2021/09/11 19:30 | Georgia Southern v Florida Atlantic | L | 6-38 |
| NCAAF | 2021/09/04 22:00 | Gardner Webb v Georgia Southern | W | 25-30 |
| NCAAF | 2020/12/23 20:00 | Georgia Southern v Louisiana Tech | W | 38-3 |
| NCAAF | 2020/12/12 23:00 | Appalachian St v Georgia Southern | L | 34-26 |
Away History
| NCAAF | 2021/10/09 23:00 | South Alabama v Texas State | L | 31-33 |
| NCAAF | 2021/10/03 00:00 | Lafayette v South Alabama | L | 20-18 |
| NCAAF | 2021/09/19 00:00 | Alcorn State v South Alabama | W | 21-28 |
| NCAAF | 2021/09/11 20:00 | South Alabama v Bowling Green | W | 22-19 |
| NCAAF | 2021/09/05 00:00 | Southern Mississippi v South Alabama | W | 7-31 |
| NCAAF | 2020/12/05 19:00 | Troy v South Alabama | L | 29-0 |
| NCAAF | 2020/11/28 20:00 | South Alabama v Arkansas State | W | 38-31 |
| NCAAF | 2020/11/21 20:30 | Georgia State v South Alabama | L | 31-14 |