[127] Southern Miss 17-27 Texas San Antonio [3] 2021-11-13 20:30
Stadium: Alamodome Round: 1
Home Manager: Jeff Traylor Away Manager: Will Hall
Head to Head
| NCAAF | 2020/11/21 20:00 | Texas-San Antonio v Southern Mississippi | L | 23-20 |
| NCAAF | 2019/11/16 23:00 | Southern Mississippi v Texas-San Antonio | W | 36-17 |
| NCAAF | 2018/10/20 23:00 | Texas-San Antonio v Southern Mississippi | W | 17-27 |
| NCAAF | 2017/10/07 23:00 | Texas-San Antonio v Southern Mississippi | W | 29-31 |
| NCAAF | 2016/10/08 16:00 | Southern Mississippi v Texas-San Antonio | L | 32-55 |
| NCAAF | 2015/10/17 23:00 | Southern Mississippi v Texas-San Antonio | W | 32-10 |
| NCAAF | 2014/11/14 01:00 | Texas-San Antonio v Southern Mississippi | L | 12-10 |
Home History
| NCAAF | 2021/11/06 19:00 | North Texas v Southern Mississippi | L | 38-14 |
| NCAAF | 2021/10/30 19:30 | Southern Mississippi v Middle Tennessee St. | L | 10-35 |
| NCAAF | 2021/10/16 19:30 | UAB v Southern Mississippi | L | 34-0 |
| NCAAF | 2021/10/09 23:00 | UTEP v Southern Mississippi | L | 26-13 |
| NCAAF | 2021/10/02 22:30 | Southern Mississippi v Rice | L | 19-24 |
| NCAAF | 2021/09/25 23:30 | Southern Mississippi v Alabama | L | 14-63 |
| NCAAF | 2021/09/18 23:00 | Troy v Southern Mississippi | L | 21-9 |
| NCAAF | 2021/09/11 23:00 | Grambling State v Southern Mississippi | W | 0-37 |
Away History
| NCAAF | 2021/11/07 02:15 | Texas-San Antonio v UTEP | W | 44-23 |
| NCAAF | 2021/10/23 23:00 | Texas-San Antonio v Louisiana Tech | W | 45-16 |
| NCAAF | 2021/10/16 22:00 | Rice v Texas-San Antonio | W | 0-45 |
| NCAAF | 2021/10/09 23:00 | Texas-San Antonio v Western Kentucky | W | 52-46 |
| NCAAF | 2021/10/02 22:00 | UNLV v Texas-San Antonio | W | 17-24 |
| NCAAF | 2021/09/25 19:30 | Texas-San Antonio v Memphis | W | 31-28 |
| NCAAF | 2021/09/18 22:00 | Middle Tennessee St. v Texas-San Antonio | W | 13-27 |
| NCAAF | 2021/09/11 22:00 | Lamar v Texas-San Antonio | W | 0-54 |