Eastern Illinois 6-22 Murray State 2021-10-02 21:00
Stadium: Roy Stewart Stadium Round: 1
Home Manager: Dean Hood Away Manager: Adam Cushing
Head to Head
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | L | 27-41 |
| NCAAF | 2019/10/05 18:00 | Eastern Illinois v Murray State | L | 17-24 |
| NCAAF | 2018/10/06 23:00 | Murray State v Eastern Illinois | L | 48-41 |
| NCAAF | 2017/10/14 20:00 | Murray State v Eastern Illinois | W | 24-27 |
Home History
| NCAAF | 2021/09/25 18:30 | Eastern Illinois v Tennessee Tech | W | 28-14 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | L | 31-24 |
| NCAAF | 2021/09/11 17:00 | Eastern Illinois v Dayton | L | 10-17 |
| NCAAF | 2021/09/04 23:00 | Eastern Illinois v South Carolina | L | 0-46 |
| NCAAF | 2021/08/28 22:00 | Eastern Illinois v Indiana State | L | 21-26 |
| NCAAF | 2021/04/03 18:00 | Jacksonville State v Eastern Illinois | L | 44-23 |
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | L | 27-41 |
| NCAAF | 2021/03/21 18:00 | Tennessee Tech v Eastern Illinois | W | 20-28 |
Away History
| NCAAF | 2021/09/18 21:00 | Murray State v Bowling Green | L | 10-27 |
| NCAAF | 2021/09/11 19:30 | Murray State v Cincinnati | L | 7-42 |
| NCAAF | 2021/09/03 00:00 | Mississippi Valley State v Murray State | W | 0-35 |
| NCAAF | 2021/04/11 19:00 | Jacksonville State v Murray State | L | 28-14 |
| NCAAF | 2021/04/03 19:00 | Murray State v Austin Peay | L | 31-34 |
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | W | 27-41 |
| NCAAF | 2021/03/21 19:00 | Tennessee State v Murray State | W | 13-35 |
| NCAAF | 2021/03/14 18:30 | Murray State v Tennessee Tech | W | 36-31 |