Stadium: Gayle and Tom Benson Stadium Round: 1
Home Manager: Eric Morris Away Manager: Eric Dooley
| NCAAF | 2021/09/05 00:00 | Prairie View v Texas Southern Tigers | W | 40-17 |
| NCAAF | 2021/04/17 20:00 | Prairie View v Arkansas Pine Bluff | L | 31-36 |
| NCAAF | 2021/03/13 21:00 | Prairie View v Grambling State | W | 17-10 |
| NCAAF | 2021/03/07 01:00 | Texas Southern Tigers v Prairie View | W | 19-20 |
| NCAAF | 2019/11/28 20:00 | Prairie View v Alabama State | W | 20-17 |
| NCAAF | 2019/11/16 20:00 | Prairie View v Edward Waters Tigers | W | 41-14 |
| NCAAF | 2019/11/09 20:00 | Arkansas Pine Bluff v Prairie View | W | 20-37 |
| NCAAF | 2019/10/24 23:30 | Jackson State v Prairie View | L | 38-35 |
| NCAAF | 2021/09/02 23:00 | Incarnate Word v Youngstown State | L | 41-44 |
| NCAAF | 2021/04/17 16:00 | Sam Houston State v Incarnate Word | L | 42-14 |
| NCAAF | 2021/04/11 00:00 | Northwestern State v Incarnate Word | L | 49-47 |
| NCAAF | 2021/03/27 16:00 | Incarnate Word v Nicholls State | L | 45-75 |
| NCAAF | 2021/03/20 19:00 | SE Louisiana v Incarnate Word | W | 45-56 |
| NCAAF | 2021/03/06 21:00 | Incarnate Word v Lamar | W | 42-20 |
| NCAAF | 2021/02/27 18:00 | Incarnate Word v McNeese State | W | 48-20 |
| NCAAF | 2019/11/23 00:30 | Central Arkansas v Incarnate Word | L | 52-35 |