Stadium: Harry Turpin Stadium Round: 1
Home Manager: Brad Laird Away Manager: Eric Morris
| NCAAF | 2021/04/11 00:00 | Northwestern State v Incarnate Word | L | 49-47 |
| NCAAF | 2019/10/26 21:00 | Northwestern State v Incarnate Word | L | 44-41 |
| NCAAF | 2021/09/25 16:00 | McNeese State v Incarnate Word | W | 0-31 |
| NCAAF | 2021/09/18 23:00 | Incarnate Word v Texas State | W | 42-34 |
| NCAAF | 2021/09/12 00:00 | Prairie View v Incarnate Word | W | 9-40 |
| NCAAF | 2021/09/02 23:00 | Incarnate Word v Youngstown State | L | 41-44 |
| NCAAF | 2021/04/17 16:00 | Sam Houston State v Incarnate Word | L | 42-14 |
| NCAAF | 2021/04/11 00:00 | Northwestern State v Incarnate Word | L | 49-47 |
| NCAAF | 2021/03/27 16:00 | Incarnate Word v Nicholls State | L | 45-75 |
| NCAAF | 2021/03/20 19:00 | SE Louisiana v Incarnate Word | W | 45-56 |
| NCAAF | 2021/09/18 23:00 | Tennessee Martin v Northwestern State | L | 35-10 |
| NCAAF | 2021/09/11 23:00 | Northwestern State v Alcorn State | L | 10-13 |
| NCAAF | 2021/09/04 23:30 | Northwestern State v North Texas | L | 14-44 |
| NCAAF | 2021/04/11 00:00 | Northwestern State v Incarnate Word | W | 49-47 |
| NCAAF | 2021/04/01 23:00 | Sam Houston State v Northwestern State | L | 24-16 |
| NCAAF | 2021/03/27 20:00 | Northwestern State v Lamar | L | 23-31 |
| NCAAF | 2021/03/20 21:00 | McNeese State v Northwestern State | L | 21-7 |
| NCAAF | 2021/03/14 00:00 | Northwestern State v SE Louisiana | L | 24-27 |