Stadium: Bob Waters Field at E.J. Whitmire Stadium Round: 1
| NCAAF | 2021/03/27 17:00 | Western Carolina v East Tennessee State | W | 17-24 |
| NCAAF | 2019/11/09 20:30 | East Tennessee State v Western Carolina | L | 20-23 |
| NCAAF | 2018/10/27 19:30 | East Tennessee State v Western Carolina | W | 45-43 |
| NCAAF | 2017/10/14 19:30 | Western Carolina v East Tennessee State | L | 49-10 |
| NCAAF | 2021/11/06 17:00 | VMI v East Tennessee State | W | 20-27 |
| NCAAF | 2021/10/23 18:00 | East Tennessee State v Furman | W | 17-13 |
| NCAAF | 2021/10/16 17:30 | East Tennessee State v Tennessee Chattanooga | L | 16-21 |
| NCAAF | 2021/10/09 20:30 | The Citadel v East Tennessee State | W | 21-48 |
| NCAAF | 2021/10/02 19:30 | Wofford v East Tennessee State | W | 21-27 |
| NCAAF | 2021/09/25 19:00 | East Tennessee State v Samford | W | 55-48 |
| NCAAF | 2021/09/18 23:30 | Delaware State v East Tennessee State | W | 6-38 |
| NCAAF | 2021/09/11 23:30 | East Tennessee State v Virginia Wise Highland Cavaliers | W | 45-14 |
| NCAAF | 2021/11/06 18:00 | Furman v Western Carolina | W | 42-43 |
| NCAAF | 2021/10/30 17:30 | Western Carolina v Wofford | W | 41-21 |
| NCAAF | 2021/10/23 18:00 | Western Carolina v The Citadel | W | 45-31 |
| NCAAF | 2021/10/09 19:30 | Mercer v Western Carolina | L | 34-24 |
| NCAAF | 2021/10/02 17:30 | Western Carolina v Tennessee Chattanooga | L | 17-45 |
| NCAAF | 2021/09/25 22:00 | Western Carolina v Gardner Webb | L | 34-52 |
| NCAAF | 2021/09/18 18:30 | Samford v Western Carolina | L | 42-37 |
| NCAAF | 2021/09/11 23:00 | Western Carolina v Oklahoma | L | 0-76 |