Stadium: William B. Greene Jr. Stadium Round: 1
Home Manager: Randy Sanders Away Manager: Rod Milstead
| NCAAF | 2021/09/11 18:00 | Georgetown v Delaware State | L | 20-14 |
| NCAAF | 2021/09/04 20:00 | Delaware State v Bowie State Bulldogs | W | 32-24 |
| NCAAF | 2021/04/17 22:00 | South Carolina State v Delaware State | L | 31-28 |
| NCAAF | 2021/04/10 22:00 | Delaware v Delaware State | L | 34-14 |
| NCAAF | 2021/04/03 17:00 | Delaware State v Howard | W | 37-28 |
| NCAAF | 2021/03/13 19:00 | Delaware State v South Carolina State | L | 9-17 |
| NCAAF | 2021/02/27 17:00 | Howard v Delaware State | W | 10-17 |
| NCAAF | 2019/11/23 19:00 | St.Francis (PA) v Delaware State | L | 35-21 |
| NCAAF | 2021/09/11 23:30 | East Tennessee State v Virginia Wise Highland Cavaliers | W | 45-14 |
| NCAAF | 2021/09/05 00:00 | East Tennessee State v Vanderbilt | W | 23-3 |
| NCAAF | 2021/04/10 22:00 | East Tennessee State v Mercer | L | 13-21 |
| NCAAF | 2021/04/03 17:30 | East Tennessee State v VMI | W | 24-20 |
| NCAAF | 2021/03/27 17:00 | Western Carolina v East Tennessee State | W | 17-24 |
| NCAAF | 2021/03/20 17:00 | East Tennessee State v The Citadel | W | 28-21 |
| NCAAF | 2021/03/13 18:00 | Furman v East Tennessee State | L | 17-13 |
| NCAAF | 2021/02/20 18:00 | Samford v East Tennessee State | W | 17-24 |