Stadium: William B. Greene Jr. Stadium Round: 1
Home Manager: Randy Sanders Away Manager:
| NCAAF | 2021/09/05 00:00 | East Tennessee State v Vanderbilt | W | 23-3 |
| NCAAF | 2021/04/10 22:00 | East Tennessee State v Mercer | L | 13-21 |
| NCAAF | 2021/04/03 17:30 | East Tennessee State v VMI | W | 24-20 |
| NCAAF | 2021/03/27 17:00 | Western Carolina v East Tennessee State | W | 17-24 |
| NCAAF | 2021/03/20 17:00 | East Tennessee State v The Citadel | W | 28-21 |
| NCAAF | 2021/03/13 18:00 | Furman v East Tennessee State | L | 17-13 |
| NCAAF | 2021/02/20 18:00 | Samford v East Tennessee State | W | 17-24 |
| NCAAF | 2019/11/23 20:30 | East Tennessee State v Vanderbilt | L | 0-38 |
| NCAAF | 2021/09/04 16:00 | Virginia Wise Highland Cavaliers v Lynchburg Dragons | W | 54-0 |
| NCAAF | 2019/11/16 18:00 | Unc Pembroke Braves v Virginia Wise Highland Cavaliers | L | 20-7 |
| NCAAF | 2019/11/09 16:00 | Virginia Wise Highland Cavaliers v Catawba College | W | 21-14 |
| NCAAF | 2019/11/02 18:00 | Virginia Wise Highland Cavaliers v Limestone Saints | L | 6-27 |
| NCAAF | 2019/10/26 22:00 | Wingate Bulldogs v Virginia Wise Highland Cavaliers | L | 45-13 |
| NCAAF | 2019/10/19 17:00 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | L | 19-21 |
| NCAAF | 2019/10/12 20:00 | Newberry Wolves v Virginia Wise Highland Cavaliers | L | 30-7 |
| NCAAF | 2019/10/05 18:00 | Lenoir Rhyne Bears v Virginia Wise Highland Cavaliers | L | 63-6 |