Wofford 21-27 East Tennessee State 2021-10-02 19:30
Stadium: William B. Greene Jr. Stadium Round: 1
Home Manager: Randy Sanders Away Manager: Josh Conklin
Head to Head
| NCAAF | 2019/10/05 19:30 | Wofford v East Tennessee State | W | 35-17 |
| NCAAF | 2018/10/20 17:30 | Wofford v East Tennessee State | W | 30-17 |
| NCAAF | 2017/10/28 17:00 | East Tennessee State v Wofford | W | 24-31 |
Home History
| NCAAF | 2021/09/25 17:30 | Wofford v VMI | L | 23-31 |
| NCAAF | 2021/09/18 22:00 | Kennesaw State v Wofford | L | 31-10 |
| NCAAF | 2021/09/04 18:00 | Wofford v Elon | W | 24-22 |
| NCAAF | 2021/04/03 17:00 | The Citadel v Wofford | L | 28-24 |
| NCAAF | 2021/03/27 17:00 | VMI v Wofford | L | 36-31 |
| NCAAF | 2021/03/13 18:00 | Wofford v Samford | L | 31-37 |
| NCAAF | 2021/02/27 17:00 | Wofford v Tennessee Chattanooga | L | 13-24 |
| NCAAF | 2021/02/20 18:00 | Mercer v Wofford | W | 14-31 |
Away History
| NCAAF | 2021/09/25 19:00 | East Tennessee State v Samford | W | 55-48 |
| NCAAF | 2021/09/18 23:30 | Delaware State v East Tennessee State | W | 6-38 |
| NCAAF | 2021/09/11 23:30 | East Tennessee State v Virginia Wise Highland Cavaliers | W | 45-14 |
| NCAAF | 2021/09/05 00:00 | East Tennessee State v Vanderbilt | W | 23-3 |
| NCAAF | 2021/04/10 22:00 | East Tennessee State v Mercer | L | 13-21 |
| NCAAF | 2021/04/03 17:30 | East Tennessee State v VMI | W | 24-20 |
| NCAAF | 2021/03/27 17:00 | Western Carolina v East Tennessee State | W | 17-24 |
| NCAAF | 2021/03/20 17:00 | East Tennessee State v The Citadel | W | 28-21 |