Stadium: Daytona Stadium Round: 1
Home Manager: Terry Sims Away Manager: Vincent Dancy
| NCAAF | 2019/09/21 23:00 | Bethune Cookman v Mississippi Valley State | L | 22-6 |
| NCAAF | 2018/10/06 20:00 | Mississippi Valley State v Bethune Cookman | L | 27-41 |
| NCAAF | 2021/10/02 20:00 | North Carolina Central v Mississippi Valley State | W | 16-17 |
| NCAAF | 2021/09/26 19:00 | Southern v Mississippi Valley State | L | 38-25 |
| NCAAF | 2021/09/18 23:00 | Mississippi Valley State v Stephen F. Austin | L | 13-58 |
| NCAAF | 2021/09/03 00:00 | Mississippi Valley State v Murray State | L | 0-35 |
| NCAAF | 2021/04/10 19:00 | Mississippi Valley State v Alabama State | L | 17-42 |
| NCAAF | 2021/04/03 20:00 | Arkansas Pine Bluff v Mississippi Valley State | L | 24-17 |
| NCAAF | 2021/03/14 19:00 | Mississippi Valley State v Jackson State | L | 7-43 |
| NCAAF | 2019/11/23 19:00 | Mississippi Valley State v Alabama | L | 13-30 |
| NCAAF | 2021/10/02 17:30 | Bethune Cookman v South Carolina State | L | 35-42 |
| NCAAF | 2021/09/25 22:00 | Bethune Cookman v Alabama State | L | 24-38 |
| NCAAF | 2021/09/16 23:30 | Alabama v Bethune Cookman | L | 30-27 |
| NCAAF | 2021/09/11 22:30 | Bethune Cookman v Central Florida | L | 14-63 |
| NCAAF | 2021/09/05 01:00 | Bethune Cookman v UTEP | L | 28-38 |
| NCAAF | 2019/11/23 20:30 | Bethune Cookman v Florida A&M | W | 31-27 |
| NCAAF | 2019/11/16 18:00 | Bethune Cookman v North Carolina A&T | L | 17-47 |
| NCAAF | 2019/11/09 19:00 | Bethune Cookman v Delaware State | L | 13-16 |