Stadium: A.W. Mumford Stadium Round: 1
| NCAAF | 2019/10/12 23:00 | Prairie View v Southern | L | 28-34 |
| NCAAF | 2018/10/13 22:00 | Southern v Prairie View | L | 38-0 |
| NCAAF | 2017/11/04 21:00 | Southern v Prairie View | L | 37-31 |
| NCAAF | 2021/10/16 17:00 | Prairie View v Bethune Cookman | W | 35-29 |
| NCAAF | 2021/09/30 23:30 | Arkansas Pine Bluff v Prairie View | W | 17-27 |
| NCAAF | 2021/09/25 21:00 | Grambling State v Prairie View | W | 10-24 |
| NCAAF | 2021/09/18 23:00 | Houston Christian v Prairie View | W | 27-37 |
| NCAAF | 2021/09/12 00:00 | Prairie View v Incarnate Word | L | 9-40 |
| NCAAF | 2021/09/05 00:00 | Prairie View v Texas Southern Tigers | W | 40-17 |
| NCAAF | 2021/04/17 20:00 | Prairie View v Arkansas Pine Bluff | L | 31-36 |
| NCAAF | 2021/03/13 21:00 | Prairie View v Grambling State | W | 17-10 |
| NCAAF | 2021/10/16 19:00 | Southern v Arkansas Pine Bluff | W | 34-7 |
| NCAAF | 2021/10/09 21:00 | Southern v Texas Southern Tigers | L | 31-35 |
| NCAAF | 2021/09/26 19:00 | Southern v Mississippi Valley State | W | 38-25 |
| NCAAF | 2021/09/18 23:00 | McNeese State v Southern | L | 31-24 |
| NCAAF | 2021/09/11 23:00 | Southern v Miles Golden Bears | W | 41-24 |
| NCAAF | 2021/09/04 23:00 | Southern v Troy | L | 3-55 |
| NCAAF | 2021/04/17 18:30 | Grambling State v Southern | W | 7-49 |
| NCAAF | 2021/04/03 21:00 | Southern v Jackson State | W | 34-14 |