Jackson State 21-17 Southern 2021-11-14 00:00
Stadium: A.W. Mumford Stadium Round: 1
Head to Head
| NCAAF | 2021/04/03 21:00 | Southern v Jackson State | L | 34-14 |
| NCAAF | 2019/11/16 20:00 | Southern v Jackson State | L | 40-34 |
| NCAAF | 2018/10/27 23:00 | Southern v Jackson State | L | 41-7 |
| NCAAF | 2017/10/21 23:00 | Jackson State v Southern | L | 17-35 |
Home History
| NCAAF | 2021/11/06 18:00 | Texas Southern Tigers v Jackson State | W | 21-41 |
| NCAAF | 2021/10/30 20:00 | Jackson State v Mississippi Valley State | W | 28-19 |
| NCAAF | 2021/10/23 18:00 | Bethune Cookman v Jackson State | W | 12-42 |
| NCAAF | 2021/10/16 19:00 | Alabama State v Jackson State | W | 7-28 |
| NCAAF | 2021/10/09 19:00 | Jackson State v Alabama | W | 61-15 |
| NCAAF | 2021/09/25 19:00 | Jackson State v Delta State | W | 24-17 |
| NCAAF | 2021/09/19 00:00 | Jackson State v UL Monroe | L | 7-12 |
| NCAAF | 2021/09/11 23:00 | Jackson State v Tennessee State | W | 38-16 |
Away History
| NCAAF | 2021/11/06 23:00 | Florida A&M v Southern | L | 29-17 |
| NCAAF | 2021/10/30 23:00 | Alcorn State v Southern | W | 35-38 |
| NCAAF | 2021/10/23 23:00 | Prairie View v Southern | L | 48-21 |
| NCAAF | 2021/10/16 19:00 | Southern v Arkansas Pine Bluff | W | 34-7 |
| NCAAF | 2021/10/09 21:00 | Southern v Texas Southern Tigers | L | 31-35 |
| NCAAF | 2021/09/26 19:00 | Southern v Mississippi Valley State | W | 38-25 |
| NCAAF | 2021/09/18 23:00 | McNeese State v Southern | L | 31-24 |
| NCAAF | 2021/09/11 23:00 | Southern v Miles Golden Bears | W | 41-24 |