Stadium: Rice-Totten Stadium Round: 1
Home Manager: Vincent Dancy Away Manager:
| NCAAF | 2021/09/18 23:00 | McNeese State v Southern | L | 31-24 |
| NCAAF | 2021/09/11 23:00 | Southern v Miles Golden Bears | W | 41-24 |
| NCAAF | 2021/09/04 23:00 | Southern v Troy | L | 3-55 |
| NCAAF | 2021/04/17 18:30 | Grambling State v Southern | W | 7-49 |
| NCAAF | 2021/04/03 21:00 | Southern v Jackson State | W | 34-14 |
| NCAAF | 2021/03/21 00:30 | Southern v Texas Southern Tigers | W | 51-23 |
| NCAAF | 2021/03/06 19:30 | Arkansas Pine Bluff v Southern | L | 33-30 |
| NCAAF | 2021/02/27 00:00 | Southern v Alabama State | W | 24-21 |
| NCAAF | 2021/09/18 23:00 | Mississippi Valley State v Stephen F. Austin | L | 13-58 |
| NCAAF | 2021/09/03 00:00 | Mississippi Valley State v Murray State | L | 0-35 |
| NCAAF | 2021/04/10 19:00 | Mississippi Valley State v Alabama State | L | 17-42 |
| NCAAF | 2021/04/03 20:00 | Arkansas Pine Bluff v Mississippi Valley State | L | 24-17 |
| NCAAF | 2021/03/14 19:00 | Mississippi Valley State v Jackson State | L | 7-43 |
| NCAAF | 2019/11/23 19:00 | Mississippi Valley State v Alabama | L | 13-30 |
| NCAAF | 2019/11/16 19:00 | Grambling State v Mississippi Valley State | L | 40-0 |
| NCAAF | 2019/11/02 18:00 | Alabama State v Mississippi Valley State | L | 27-0 |