Southern 31-35 Texas Southern 2021-10-09 21:00
Stadium: Globe Life Park Round: 1
Head to Head
| NCAAF | 2021/03/21 00:30 | Southern v Texas Southern Tigers | W | 51-23 |
| NCAAF | 2019/10/19 19:00 | Southern v Texas Southern Tigers | W | 28-21 |
| NCAAF | 2018/10/20 19:00 | Texas Southern Tigers v Southern | W | 7-21 |
| NCAAF | 2017/11/11 23:00 | Texas Southern Tigers v Southern | W | 7-33 |
Home History
| NCAAF | 2021/09/26 19:00 | Southern v Mississippi Valley State | W | 38-25 |
| NCAAF | 2021/09/18 23:00 | McNeese State v Southern | L | 31-24 |
| NCAAF | 2021/09/11 23:00 | Southern v Miles Golden Bears | W | 41-24 |
| NCAAF | 2021/09/04 23:00 | Southern v Troy | L | 3-55 |
| NCAAF | 2021/04/17 18:30 | Grambling State v Southern | W | 7-49 |
| NCAAF | 2021/04/03 21:00 | Southern v Jackson State | W | 34-14 |
| NCAAF | 2021/03/21 00:30 | Southern v Texas Southern Tigers | W | 51-23 |
| NCAAF | 2021/03/06 19:30 | Arkansas Pine Bluff v Southern | L | 33-30 |
Away History
| NCAAF | 2021/10/02 19:00 | Texas Southern Tigers v North American Stallions | W | 69-0 |
| NCAAF | 2021/09/25 22:30 | Texas Southern Tigers v Rice | L | 34-48 |
| NCAAF | 2021/09/11 23:00 | Texas Southern Tigers v Baylor | L | 7-66 |
| NCAAF | 2021/09/05 00:00 | Prairie View v Texas Southern Tigers | L | 40-17 |
| NCAAF | 2021/03/21 00:30 | Southern v Texas Southern Tigers | L | 51-23 |
| NCAAF | 2021/03/07 01:00 | Texas Southern Tigers v Prairie View | L | 19-20 |
| NCAAF | 2019/11/23 21:00 | Texas Southern Tigers v Arkansas Pine Bluff | L | 13-45 |
| NCAAF | 2019/11/09 20:00 | Alabama State v Texas Southern Tigers | L | 27-21 |