[5] Michigan 33-37 Michigan State [8] 2021-10-30 16:00
Stadium: Spartan Stadium Round: 1
Home Manager: Melvin Tucker Away Manager: Jim Harbaugh
Head to Head
| NCAAF | 2020/10/31 16:00 | Michigan State v Michigan | L | 27-24 |
| NCAAF | 2019/11/16 17:00 | Michigan State v Michigan | W | 10-44 |
| NCAAF | 2018/10/20 16:00 | Michigan v Michigan State | W | 21-7 |
| NCAAF | 2017/10/07 23:30 | Michigan State v Michigan | L | 14-10 |
| NCAAF | 2016/10/29 16:00 | Michigan v Michigan State | W | 32-23 |
| NCAAF | 2015/10/17 19:30 | Michigan v Michigan State | L | 23-27 |
| NCAAF | 2014/10/25 19:30 | Michigan State v Michigan | L | 35-11 |
| NCAAF | 2012/10/20 12:00 | Michigan v Michigan State | W | 12-10 |
Home History
| NCAAF | 2021/10/23 16:00 | Northwestern v Michigan | W | 7-33 |
| NCAAF | 2021/10/09 23:30 | Michigan v Nebraska | W | 32-29 |
| NCAAF | 2021/10/02 16:00 | Michigan v Wisconsin | W | 38-17 |
| NCAAF | 2021/09/25 19:30 | Rutgers v Michigan | W | 13-20 |
| NCAAF | 2021/09/18 16:00 | Northern Illinois v Michigan | W | 10-63 |
| NCAAF | 2021/09/12 00:00 | Washington v Michigan | W | 10-31 |
| NCAAF | 2021/09/04 16:00 | Western Michigan v Michigan | W | 14-47 |
| NCAAF | 2020/11/28 17:00 | Penn State v Michigan | L | 27-17 |
Away History
| NCAAF | 2021/10/16 16:00 | Michigan State v Indiana | W | 20-15 |
| NCAAF | 2021/10/09 16:00 | Michigan State v Rutgers | W | 31-13 |
| NCAAF | 2021/10/02 23:30 | Western Kentucky v Michigan State | W | 31-48 |
| NCAAF | 2021/09/25 23:00 | Nebraska v Michigan State | W | 20-23 |
| NCAAF | 2021/09/18 16:00 | Michigan State v Miami Florida | W | 38-17 |
| NCAAF | 2021/09/11 16:00 | Youngstown State v Michigan State | W | 14-42 |
| NCAAF | 2021/09/04 01:00 | Michigan State v Northwestern | W | 38-21 |
| NCAAF | 2020/12/12 17:00 | Michigan State v Penn State | L | 24-39 |