[99] Western Kentucky 31-48 Michigan State [17] 2021-10-02 23:30
Stadium: Spartan Stadium Round: 1
Home Manager: Melvin Tucker Away Manager: Tyson Helton
Home History
| NCAAF | 2021/09/26 00:00 | Indiana v Western Kentucky | L | 33-31 |
| NCAAF | 2021/09/11 15:30 | Western Kentucky v Army | L | 35-38 |
| NCAAF | 2021/09/03 00:00 | Tennessee Martin v Western Kentucky | W | 21-59 |
| NCAAF | 2020/12/26 20:30 | Western Kentucky v Georgia State | L | 21-39 |
| NCAAF | 2020/12/06 17:00 | Western Kentucky v Charlotte | W | 37-19 |
| NCAAF | 2020/11/21 19:00 | Florida Intl v Western Kentucky | W | 21-38 |
| NCAAF | 2020/11/14 20:30 | Southern Mississippi v Western Kentucky | W | 7-10 |
| NCAAF | 2020/11/07 23:00 | Western Kentucky v Florida Atlantic | L | 6-10 |
Away History
| NCAAF | 2021/09/25 23:00 | Nebraska v Michigan State | W | 20-23 |
| NCAAF | 2021/09/18 16:00 | Michigan State v Miami Florida | W | 38-17 |
| NCAAF | 2021/09/11 16:00 | Youngstown State v Michigan State | W | 14-42 |
| NCAAF | 2021/09/04 01:00 | Michigan State v Northwestern | W | 38-21 |
| NCAAF | 2020/12/12 17:00 | Michigan State v Penn State | L | 24-39 |
| NCAAF | 2020/12/05 17:00 | Ohio State v Michigan State | L | 52-12 |
| NCAAF | 2020/11/28 20:30 | Northwestern v Michigan State | W | 20-29 |
| NCAAF | 2020/11/14 17:00 | Indiana v Michigan State | L | 24-0 |