Ohio State 27-42 Michigan 2021-11-27 17:00
Stadium: Michigan Stadium Round: 1
Home Manager: Jim Harbaugh Away Manager: Ryan Day
Head to Head
| NCAAF | 2019/11/30 17:00 | Ohio State v Michigan | W | 56-27 |
| NCAAF | 2018/11/24 17:00 | Michigan v Ohio State | W | 39-62 |
| NCAAF | 2017/11/25 17:00 | Ohio State v Michigan | W | 31-20 |
| NCAAF | 2016/11/26 17:00 | Michigan v Ohio State | W | 27-30 |
| NCAAF | 2015/11/28 17:00 | Michigan v Ohio State | W | 13-42 |
| NCAAF | 2014/11/29 17:00 | Ohio State v Michigan | W | 42-28 |
| NCAAF | 2012/11/24 12:00 | Ohio State v Michigan | W | 26-21 |
| NCAAF | 2011/11/26 12:00 | Michigan v Ohio State | L | 40-34 |
Home History
| NCAAF | 2021/11/20 17:00 | Michigan State v Ohio State | W | 7-56 |
| NCAAF | 2021/11/13 20:30 | Purdue v Ohio State | W | 31-59 |
| NCAAF | 2021/11/06 16:00 | Ohio State v Nebraska | W | 26-17 |
| NCAAF | 2021/10/30 23:30 | Penn State v Ohio State | W | 24-33 |
| NCAAF | 2021/10/23 23:30 | Ohio State v Indiana | W | 54-7 |
| NCAAF | 2021/10/09 16:00 | Maryland v Ohio State | W | 17-66 |
| NCAAF | 2021/10/02 19:30 | Ohio State v Rutgers | W | 52-13 |
| NCAAF | 2021/09/25 23:30 | Akron v Ohio State | W | 7-59 |
Away History
| NCAAF | 2021/11/20 20:30 | Michigan v Maryland | W | 59-18 |
| NCAAF | 2021/11/13 17:00 | Michigan v Penn State | W | 21-17 |
| NCAAF | 2021/11/06 23:30 | Indiana v Michigan | W | 7-29 |
| NCAAF | 2021/10/30 16:00 | Michigan v Michigan State | L | 33-37 |
| NCAAF | 2021/10/23 16:00 | Northwestern v Michigan | W | 7-33 |
| NCAAF | 2021/10/09 23:30 | Michigan v Nebraska | W | 32-29 |
| NCAAF | 2021/10/02 16:00 | Michigan v Wisconsin | W | 38-17 |
| NCAAF | 2021/09/25 19:30 | Rutgers v Michigan | W | 13-20 |