[38] Mississippi 31-26 Tennessee [43] 2021-10-16 23:30
Stadium: Neyland Stadium Round: 1
Home Manager: Josh Heupel Away Manager: Lane Kiffin
Head to Head
| NCAAF | 2014/10/18 23:00 | Mississippi v Tennessee | W | 34-3 |
| NCAAF | 2010/11/13 12:00 | Tennessee v Mississippi | L | 52-14 |
| NCAAF | 2009/11/14 12:00 | Mississippi v Tennessee | W | 42-17 |
| NCAAF | 2005/10/01 12:00 | Tennessee v Mississippi | L | 27-10 |
| NCAAF | 2004/10/16 12:00 | Mississippi v Tennessee | L | 17-21 |
Home History
| NCAAF | 2021/10/09 16:00 | Arkansas v Mississippi | W | 51-52 |
| NCAAF | 2021/10/02 19:30 | Mississippi v Alabama | L | 21-42 |
| NCAAF | 2021/09/19 00:00 | Tulane v Mississippi | W | 21-61 |
| NCAAF | 2021/09/11 23:30 | Austin Peay v Mississippi | W | 17-54 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | W | 24-43 |
| NCAAF | 2021/01/02 17:30 | Mississippi v Indiana | W | 26-20 |
| NCAAF | 2020/12/19 20:30 | Mississippi v LSU | L | 48-53 |
| NCAAF | 2020/11/28 21:00 | Mississippi State v Mississippi | W | 24-31 |
Away History
| NCAAF | 2021/10/09 16:00 | South Carolina v Tennessee | W | 20-45 |
| NCAAF | 2021/10/02 16:00 | Tennessee v Missouri | W | 62-24 |
| NCAAF | 2021/09/25 23:00 | Tennessee v Florida | L | 14-38 |
| NCAAF | 2021/09/18 16:00 | Tennessee Tech v Tennessee | W | 0-56 |
| NCAAF | 2021/09/11 16:00 | Pittsburgh v Tennessee | L | 41-34 |
| NCAAF | 2021/09/03 00:00 | Bowling Green v Tennessee | W | 6-38 |
| NCAAF | 2020/12/19 17:00 | Texas A&M v Tennessee | L | 34-13 |
| NCAAF | 2020/12/12 21:00 | Tennessee v Vanderbilt | W | 42-17 |