[53] South Carolina 20-45 Tennessee [72] 2021-10-09 16:00
Stadium: Neyland Stadium Round: 1
Home Manager: Josh Heupel Away Manager: Shane Beamer
Head to Head
| NCAAF | 2020/09/26 23:30 | Tennessee v South Carolina | L | 31-27 |
| NCAAF | 2019/10/26 20:00 | South Carolina v Tennessee | L | 21-41 |
| NCAAF | 2019/10/02 17:20 | South Carolina v Tennessee | D | 0-0 |
| NCAAF | 2018/10/27 23:30 | Tennessee v South Carolina | W | 24-27 |
| NCAAF | 2017/10/14 16:00 | South Carolina v Tennessee | W | 15-9 |
| NCAAF | 2016/10/29 23:15 | Tennessee v South Carolina | W | 21-24 |
| NCAAF | 2015/11/07 21:00 | Tennessee v South Carolina | L | 27-24 |
| NCAAF | 2014/11/01 23:30 | South Carolina v Tennessee | L | 42-45 |
Home History
| NCAAF | 2021/10/02 19:30 | Troy v South Carolina | W | 14-23 |
| NCAAF | 2021/09/25 23:00 | Kentucky v South Carolina | L | 16-10 |
| NCAAF | 2021/09/18 23:00 | South Carolina v Georgia | L | 13-40 |
| NCAAF | 2021/09/11 16:00 | South Carolina v East Carolina | W | 20-17 |
| NCAAF | 2021/09/04 23:00 | Eastern Illinois v South Carolina | W | 0-46 |
| NCAAF | 2020/12/06 00:30 | South Carolina v Kentucky | L | 18-41 |
| NCAAF | 2020/11/29 00:30 | Georgia v South Carolina | L | 45-16 |
| NCAAF | 2020/11/22 00:30 | Missouri v South Carolina | L | 17-10 |
Away History
| NCAAF | 2021/10/02 16:00 | Tennessee v Missouri | W | 62-24 |
| NCAAF | 2021/09/25 23:00 | Tennessee v Florida | L | 14-38 |
| NCAAF | 2021/09/18 16:00 | Tennessee Tech v Tennessee | W | 0-56 |
| NCAAF | 2021/09/11 16:00 | Pittsburgh v Tennessee | L | 41-34 |
| NCAAF | 2021/09/03 00:00 | Bowling Green v Tennessee | W | 6-38 |
| NCAAF | 2020/12/19 17:00 | Texas A&M v Tennessee | L | 34-13 |
| NCAAF | 2020/12/12 21:00 | Tennessee v Vanderbilt | W | 42-17 |
| NCAAF | 2020/12/05 20:30 | Florida v Tennessee | L | 31-19 |