[52] Duke 7-38 North Carolina [92] 2021-10-02 16:00
Stadium: Kenan Stadium Round: 1
Home Manager: Mack Brown Away Manager: David Cutcliffe
Head to Head
| NCAAF | 2020/11/07 17:00 | North Carolina v Duke | L | 56-24 |
| NCAAF | 2019/10/26 20:00 | Duke v North Carolina | L | 17-20 |
| NCAAF | 2018/11/10 17:20 | North Carolina v Duke | W | 35-42 |
| NCAAF | 2017/09/23 19:30 | Duke v North Carolina | W | 27-17 |
| NCAAF | 2016/11/11 00:30 | North Carolina v Duke | W | 27-28 |
| NCAAF | 2015/11/07 17:00 | North Carolina v Duke | L | 66-31 |
| NCAAF | 2014/11/21 00:30 | Duke v North Carolina | L | 20-45 |
| NCAAF | 2012/10/20 12:00 | Duke v North Carolina | W | 33-30 |
Home History
| NCAAF | 2021/09/25 20:00 | Kansas v Duke | W | 33-52 |
| NCAAF | 2021/09/18 20:00 | Northwestern v Duke | W | 23-30 |
| NCAAF | 2021/09/11 00:00 | North Carolina A&T v Duke | W | 17-45 |
| NCAAF | 2021/09/03 23:00 | Duke v Charlotte | L | 28-31 |
| NCAAF | 2020/12/12 21:00 | Duke v Florida State | L | 35-56 |
| NCAAF | 2020/12/06 01:00 | Miami Florida v Duke | L | 48-0 |
| NCAAF | 2020/11/29 00:00 | Duke v Georgia Tech | L | 33-56 |
| NCAAF | 2020/11/07 17:00 | North Carolina v Duke | L | 56-24 |
Away History
| NCAAF | 2021/09/25 23:30 | North Carolina v Georgia Tech | L | 22-45 |
| NCAAF | 2021/09/18 23:30 | Virginia v North Carolina | W | 39-59 |
| NCAAF | 2021/09/11 23:30 | Georgia State v North Carolina | W | 17-59 |
| NCAAF | 2021/09/03 22:00 | North Carolina v Virginia Tech | L | 10-17 |
| NCAAF | 2021/01/03 01:00 | North Carolina v Texas A&M | L | 27-41 |
| NCAAF | 2020/12/12 20:40 | North Carolina v Miami Florida | W | 62-26 |
| NCAAF | 2020/12/05 17:00 | Western Carolina v North Carolina | W | 9-49 |
| NCAAF | 2020/11/27 20:30 | Notre Dame v North Carolina | L | 31-17 |