[117] Vanderbilt 17-31 Mississippi [22] 2021-11-21 00:30
Stadium: Vaught-Hemingway Stadium Round: 1
Home Manager: Lane Kiffin Away Manager: Clark Lea
Head to Head
| NCAAF | 2020/10/31 20:00 | Mississippi v Vanderbilt | L | 54-21 |
| NCAAF | 2019/10/05 23:30 | Vanderbilt v Mississippi | L | 6-31 |
| NCAAF | 2018/11/18 00:30 | Mississippi v Vanderbilt | W | 29-36 |
| NCAAF | 2017/10/14 19:30 | Vanderbilt v Mississippi | L | 35-57 |
| NCAAF | 2016/11/20 01:00 | Mississippi v Vanderbilt | W | 17-38 |
| NCAAF | 2015/09/26 23:00 | Mississippi v Vanderbilt | L | 27-16 |
| NCAAF | 2014/09/06 20:30 | Vanderbilt v Mississippi | L | 3-41 |
| NCAAF | 2012/11/10 12:00 | Mississippi v Vanderbilt | W | 26-27 |
Home History
| NCAAF | 2021/11/14 00:00 | Kentucky v Vanderbilt | L | 34-17 |
| NCAAF | 2021/10/30 19:00 | Missouri v Vanderbilt | L | 37-28 |
| NCAAF | 2021/10/23 20:00 | Mississippi State v Vanderbilt | L | 45-6 |
| NCAAF | 2021/10/16 20:00 | Vanderbilt v South Carolina | L | 20-21 |
| NCAAF | 2021/10/09 16:00 | Vanderbilt v Florida | L | 0-42 |
| NCAAF | 2021/10/02 23:30 | Connecticut v Vanderbilt | W | 28-30 |
| NCAAF | 2021/09/25 16:00 | Georgia v Vanderbilt | L | 62-0 |
| NCAAF | 2021/09/19 00:00 | Stanford v Vanderbilt | L | 41-23 |
Away History
| NCAAF | 2021/11/14 00:00 | Texas A&M v Mississippi | W | 19-29 |
| NCAAF | 2021/11/06 16:00 | Liberty v Mississippi | W | 14-27 |
| NCAAF | 2021/10/30 23:00 | Mississippi v Auburn | L | 20-31 |
| NCAAF | 2021/10/23 19:30 | LSU v Mississippi | W | 17-31 |
| NCAAF | 2021/10/16 23:30 | Mississippi v Tennessee | W | 31-26 |
| NCAAF | 2021/10/09 16:00 | Arkansas v Mississippi | W | 51-52 |
| NCAAF | 2021/10/02 19:30 | Mississippi v Alabama | L | 21-42 |
| NCAAF | 2021/09/19 00:00 | Tulane v Mississippi | W | 21-61 |