[76] Kevin Anderson 2-6,4-6 Karen Khachanov [30] 2021-08-17 01:25
Stadium: Stadium 3 Round: 24 Ground: Hardcourt outdoor
Head to Head
| ATP Great Ocean Road Open | 2021/02/04 23:30 | Kevin Anderson v Karen Khachanov | 3-6,6-7 |
| ATP Miami | 2018/03/26 21:05 | Karen Khachanov v Kevin Anderson | 6-4,2-6,3-6 |
Home History
| ATP Cincinnati | 2021/08/15 15:00 | Kevin Anderson v Steve Johnson | 7-6,6-4 |
| ATP Cincinnati | 2021/08/14 14:00 | Lorenzo Musetti v Kevin Anderson | 3-6,3-6 |
| ATP Washington | 2021/08/02 19:45 | Kevin Anderson v Jenson Brooksby | 6-7,3-6 |
| ATP Atlanta | 2021/07/28 02:15 | Kevin Anderson v Nick Kyrgios | 6-7,3-6 |
| ATP Newport | 2021/07/18 18:30 | Kevin Anderson v Jenson Brooksby | 7-6,6-4 |
| ATP Newport | 2021/07/17 17:00 | Alexander Bublik v Kevin Anderson | 6-4,6-7,5-7 |
| ATP Newport | 2021/07/15 18:20 | Jack Sock v Kevin Anderson | 7-6,2-6,4-6 |
| ATP Newport | 2021/07/14 15:00 | Sebastian Ofner v Kevin Anderson | 5-7,6-7 |
Away History
| ATP Toronto | 2021/08/12 15:00 | Karen Khachanov v Stefanos Tsitsipas | 3-6,2-6 |
| ATP Toronto | 2021/08/11 17:30 | Aslan Karatsev v Karen Khachanov | 6-7,4-6 |
| ATP Toronto | 2021/08/10 15:00 | Cameron Norrie v Karen Khachanov | 4-6,7-5,4-6 |
| Olympics 2020 - Men | 2021/08/01 07:40 | Alexander Zverev v Karen Khachanov | 6-3,6-1 |
| Olympics 2020 - Men | 2021/07/30 06:00 | Karen Khachanov v Pablo Carreno Busta | 6-3,6-3 |
| Olympics 2020 - Men | 2021/07/29 06:00 | Karen Khachanov v Ugo Humbert | 7-6,4-6,6-3 |
| Olympics 2020 - Men | 2021/07/28 03:15 | Diego Schwartzman v Karen Khachanov | 1-6,6-2,1-6 |
| Olympics 2020 - Men | 2021/07/27 06:20 | James Duckworth v Karen Khachanov | 5-7,1-6 |