Round: 1
| NCAAF | 2021/10/16 17:00 | Edward Waters Tigers v Kentucky Thorobreds | L | 36-76 |
| NCAAF | 2021/10/09 18:00 | Albany State Golden Rams v Edward Waters Tigers | L | 30-0 |
| NCAAF | 2021/10/02 18:00 | Morehouse College Maroon Tigers v Edward Waters Tigers | W | 13-37 |
| NCAAF | 2021/09/25 22:00 | Edward Waters Tigers v Lane College Dragons | L | 35-45 |
| NCAAF | 2021/09/09 23:30 | Benedict College v Edward Waters Tigers | L | 44-3 |
| NCAAF | 2021/02/21 19:00 | Jackson State v Edward Waters Tigers | L | 53-0 |
| NCAAF | 2019/11/16 20:00 | Prairie View v Edward Waters Tigers | L | 41-14 |
| NCAAF | 2019/11/09 20:00 | Edward Waters Tigers v Savannah State | L | 19-49 |
| NCAAF | 2021/10/16 17:00 | Central State v Tuskegee | L | 0-29 |
| NCAAF | 2021/10/09 18:00 | Fort Valley State v Central State | L | 35-14 |
| NCAAF | 2021/10/02 17:00 | Central State v Allen Yellow Jackets | L | 34-46 |
| NCAAF | 2021/09/25 23:00 | Miles Golden Bears v Central State | L | 55-4 |
| NCAAF | 2021/09/18 17:00 | Shaw Bears v Central State | L | 52-0 |
| NCAAF | 2021/09/11 17:00 | Lincoln University v Central State | W | 7-19 |
| NCAAF | 2021/08/28 19:00 | Central State v Kentucky Thorobreds | L | 6-20 |
| NCAAF | 2019/11/09 18:00 | Central State v Kentucky Thorobreds | L | 28-34 |