Stadium: Alumni Stadium (Kentucky State University) Round: 1
| NCAAF | 2021/08/28 19:00 | Central State v Kentucky Thorobreds | W | 6-20 |
| NCAAF | 2019/11/09 18:00 | Central State v Kentucky Thorobreds | W | 28-34 |
| NCAAF | 2018/09/22 20:00 | Kentucky Thorobreds v Central State | L | 6-24 |
| NCAAF | 2021/10/30 18:00 | Tuskegee v Kentucky Thorobreds | W | 35-42 |
| NCAAF | 2021/10/23 17:00 | Kentucky Thorobreds v Miles Golden Bears | L | 21-28 |
| NCAAF | 2021/10/16 17:00 | Edward Waters Tigers v Kentucky Thorobreds | W | 36-76 |
| NCAAF | 2021/10/09 18:00 | Kentucky Thorobreds v Lane College Dragons | W | 49-14 |
| NCAAF | 2021/10/02 17:00 | Kentucky Thorobreds v Savannah State | L | 17-21 |
| NCAAF | 2021/09/25 19:00 | Kentucky Thorobreds v Benedict College | W | 34-28 |
| NCAAF | 2021/09/18 19:00 | Tennessee State v Kentucky Thorobreds | L | 41-7 |
| NCAAF | 2021/09/11 17:00 | Kentucky Thorobreds v Kentucky Wesleyan | L | 25-26 |
| NCAAF | 2021/10/30 17:00 | Central State v Lane College Dragons | L | 14-16 |
| NCAAF | 2021/10/23 18:00 | Edward Waters Tigers v Central State | L | 56-19 |
| NCAAF | 2021/10/16 17:00 | Central State v Tuskegee | L | 0-29 |
| NCAAF | 2021/10/09 18:00 | Fort Valley State v Central State | L | 35-14 |
| NCAAF | 2021/10/02 17:00 | Central State v Allen Yellow Jackets | L | 34-46 |
| NCAAF | 2021/09/25 23:00 | Miles Golden Bears v Central State | L | 55-4 |
| NCAAF | 2021/09/18 17:00 | Shaw Bears v Central State | L | 52-0 |
| NCAAF | 2021/09/11 17:00 | Lincoln University v Central State | W | 7-19 |