Stadium: Robert B. Redman Stadium Round: 1
| NCAAF | 2021/10/23 17:00 | East Stroudsburg Warriors v Bloomsburg Huskies | L | 35-14 |
| NCAAF | 2021/10/16 18:00 | Bloomsburg Huskies v Lock Haven | W | 44-0 |
| NCAAF | 2021/10/09 18:00 | Bloomsburg Huskies v Kutztown Golden Bears | L | 7-34 |
| NCAAF | 2021/10/02 18:00 | West Chester Golden Rams v Bloomsburg Huskies | L | 21-20 |
| NCAAF | 2021/09/25 17:00 | Shippensburg Raiders v Bloomsburg Huskies | L | 51-7 |
| NCAAF | 2021/09/18 18:00 | Bloomsburg Huskies v Gannon University Golden Knights | W | 31-27 |
| NCAAF | 2021/09/11 22:00 | Seton Hill Griffins v Bloomsburg Huskies | L | 13-7 |
| NCAAF | 2021/09/04 18:30 | Stonehill v Bloomsburg Huskies | L | 35-13 |
| NCAAF | 2021/10/23 16:00 | Shepherd Rams v West Chester Golden Rams | W | 42-38 |
| NCAAF | 2021/10/16 18:00 | Millersville University of Pennsylvania Marauders v Shepherd Rams | W | 13-38 |
| NCAAF | 2021/10/09 17:00 | Lock Haven v Shepherd Rams | W | 21-75 |
| NCAAF | 2021/10/02 16:00 | Shepherd Rams v Shippensburg Raiders | W | 59-27 |
| NCAAF | 2021/09/25 16:00 | Shepherd Rams v Kutztown Golden Bears | L | 29-37 |
| NCAAF | 2021/09/18 18:00 | Iup Crimson Hawks v Shepherd Rams | W | 21-37 |
| NCAAF | 2021/09/11 16:00 | Gannon University Golden Knights v Shepherd Rams | W | 26-56 |
| NCAAF | 2021/09/02 23:00 | Ohio Dominican Panthers v Shepherd Rams | W | 30-35 |