Stadium: Ram Stadium Round: 1
| NCAAF | 2021/10/30 18:00 | Bloomsburg Huskies v Shepherd Rams | W | 18-62 |
| NCAAF | 2021/10/23 16:00 | Shepherd Rams v West Chester Golden Rams | W | 42-38 |
| NCAAF | 2021/10/16 18:00 | Millersville University of Pennsylvania Marauders v Shepherd Rams | W | 13-38 |
| NCAAF | 2021/10/09 17:00 | Lock Haven v Shepherd Rams | W | 21-75 |
| NCAAF | 2021/10/02 16:00 | Shepherd Rams v Shippensburg Raiders | W | 59-27 |
| NCAAF | 2021/09/25 16:00 | Shepherd Rams v Kutztown Golden Bears | L | 29-37 |
| NCAAF | 2021/09/18 18:00 | Iup Crimson Hawks v Shepherd Rams | W | 21-37 |
| NCAAF | 2021/09/11 16:00 | Gannon University Golden Knights v Shepherd Rams | W | 26-56 |
| NCAAF | 2021/10/30 17:05 | East Stroudsburg Warriors v Shippensburg Raiders | L | 23-24 |
| NCAAF | 2021/10/23 17:00 | East Stroudsburg Warriors v Bloomsburg Huskies | W | 35-14 |
| NCAAF | 2021/10/16 16:00 | West Chester Golden Rams v East Stroudsburg Warriors | L | 42-24 |
| NCAAF | 2021/10/09 18:05 | East Stroudsburg Warriors v Millersville University of Pennsylvania Marauders | W | 27-7 |
| NCAAF | 2021/10/02 16:05 | Kutztown Golden Bears v East Stroudsburg Warriors | L | 21-14 |
| NCAAF | 2021/09/25 22:00 | Lock Haven v East Stroudsburg Warriors | W | 21-45 |
| NCAAF | 2021/09/18 17:05 | East Stroudsburg Warriors v Mercyhurst | W | 17-7 |
| NCAAF | 2021/09/11 22:00 | Slippery Rock v East Stroudsburg Warriors | L | 22-7 |