Stadium: Francis G. Welch Stadium Round: 1
| NCAAF | 2021/10/30 18:00 | Fort Hays State University Tigers v Emporia State | W | 12-15 |
| NCAAF | 2021/10/23 19:00 | Emporia State v Missouri Southern Lions | W | 24-21 |
| NCAAF | 2021/10/16 18:00 | Emporia State v Nebraska Kearney | L | 35-42 |
| NCAAF | 2021/10/09 18:00 | Central Missouri Mules v Emporia State | L | 45-38 |
| NCAAF | 2021/10/02 18:00 | Emporia State v Washburn Ichabods Football | W | 35-30 |
| NCAAF | 2021/09/26 00:00 | Pittsburgh State Gorillas v Emporia State | L | 30-28 |
| NCAAF | 2021/09/18 23:00 | Missouri Western Griffons v Emporia State | L | 38-37 |
| NCAAF | 2021/09/12 00:00 | Emporia State v Central Oklahoma | W | 31-21 |
| NCAAF | 2021/10/30 19:00 | Blue Tigers v Central Missouri Mules | L | 35-77 |
| NCAAF | 2021/10/23 19:00 | Nebraska Kearney v Blue Tigers | L | 56-0 |
| NCAAF | 2021/10/16 18:00 | Pittsburgh State Gorillas v Blue Tigers | L | 59-7 |
| NCAAF | 2021/10/09 19:00 | Blue Tigers v Missouri Southern Lions | L | 32-52 |
| NCAAF | 2021/10/02 19:00 | Central Oklahoma v Blue Tigers | L | 69-28 |
| NCAAF | 2021/09/25 18:00 | Blue Tigers v Northeastern State Riverhawks | L | 48-49 |
| NCAAF | 2021/09/19 00:00 | Fort Hays State University Tigers v Blue Tigers | L | 72-0 |
| NCAAF | 2021/09/02 23:00 | Blue Tigers v Washburn Ichabods Football | L | 12-76 |