Round: 1
| NCAAF | 2021/10/23 18:00 | Edward Waters Tigers v Central State | W | 56-19 |
| NCAAF | 2021/10/16 17:00 | Edward Waters Tigers v Kentucky Thorobreds | L | 36-76 |
| NCAAF | 2021/10/09 18:00 | Albany State Golden Rams v Edward Waters Tigers | L | 30-0 |
| NCAAF | 2021/10/02 18:00 | Morehouse College Maroon Tigers v Edward Waters Tigers | W | 13-37 |
| NCAAF | 2021/09/25 22:00 | Edward Waters Tigers v Lane College Dragons | L | 35-45 |
| NCAAF | 2021/09/09 23:30 | Benedict College v Edward Waters Tigers | L | 44-3 |
| NCAAF | 2021/02/21 19:00 | Jackson State v Edward Waters Tigers | L | 53-0 |
| NCAAF | 2019/11/16 20:00 | Prairie View v Edward Waters Tigers | L | 41-14 |
| NCAAF | 2021/10/23 17:00 | Kentucky Thorobreds v Miles Golden Bears | W | 21-28 |
| NCAAF | 2021/10/16 19:00 | Lane College Dragons v Miles Golden Bears | W | 31-34 |
| NCAAF | 2021/10/09 21:00 | Miles Golden Bears v Benedict College | L | 21-24 |
| NCAAF | 2021/10/02 23:00 | Miles Golden Bears v Albany State Golden Rams | L | 3-31 |
| NCAAF | 2021/09/25 23:00 | Miles Golden Bears v Central State | W | 55-4 |
| NCAAF | 2021/09/18 18:00 | Morehouse College Maroon Tigers v Miles Golden Bears | W | 14-37 |
| NCAAF | 2021/09/11 23:00 | Southern v Miles Golden Bears | L | 41-24 |
| NCAAF | 2021/09/04 22:00 | Alabama State v Miles Golden Bears | L | 14-13 |