Stadium: Albert J. Sloan–Alumni Stadium Round: 1
| NCAAF | 2019/11/09 19:00 | Tuskegee v Miles Golden Bears | W | 6-20 |
| NCAAF | 2018/11/03 19:00 | Miles Golden Bears v Tuskegee | W | 31-27 |
| NCAAF | 2021/10/30 22:00 | Edward Waters Tigers v Miles Golden Bears | W | 9-16 |
| NCAAF | 2021/10/23 17:00 | Kentucky Thorobreds v Miles Golden Bears | W | 21-28 |
| NCAAF | 2021/10/16 19:00 | Lane College Dragons v Miles Golden Bears | W | 31-34 |
| NCAAF | 2021/10/09 21:00 | Miles Golden Bears v Benedict College | L | 21-24 |
| NCAAF | 2021/10/02 23:00 | Miles Golden Bears v Albany State Golden Rams | L | 3-31 |
| NCAAF | 2021/09/25 23:00 | Miles Golden Bears v Central State | W | 55-4 |
| NCAAF | 2021/09/18 18:00 | Morehouse College Maroon Tigers v Miles Golden Bears | W | 14-37 |
| NCAAF | 2021/09/11 23:00 | Southern v Miles Golden Bears | L | 41-24 |
| NCAAF | 2021/10/30 18:00 | Tuskegee v Kentucky Thorobreds | L | 35-42 |
| NCAAF | 2021/10/23 18:00 | Tuskegee v Lane College Dragons | L | 17-21 |
| NCAAF | 2021/10/16 17:00 | Central State v Tuskegee | W | 0-29 |
| NCAAF | 2021/10/10 00:00 | Morehouse College Maroon Tigers v Tuskegee | L | 31-15 |
| NCAAF | 2021/10/02 18:00 | Tuskegee v Clark Atlanta University | W | 21-0 |
| NCAAF | 2021/09/25 21:00 | Tuskegee v Alabama | L | 35-45 |
| NCAAF | 2021/09/11 18:00 | Tuskegee v West Alabama Tigers | L | 7-33 |
| NCAAF | 2021/09/05 23:00 | Fort Valley State v Tuskegee | L | 30-0 |